Reactome | Gbeta:gamma activation of PLC beta

Gbeta:gamma activation of PLC beta

Stable Identifier

R-HSA-398040

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol, plasma membrane

Locations in the PathwayBrowser

Expand all

Signal Transduction (Homo sapiens)

- Signaling by GPCR (Homo sapiens)
  - GPCR downstream signalling (Homo sapiens)
    - G-protein beta:gamma signalling (Homo sapiens)
      - G beta:gamma signalling through PLC beta (Homo sapiens)
        
        Gbeta:gamma activation of PLC beta (Homo sapiens)
- Signaling by WNT (Homo sapiens)
  - Beta-catenin independent WNT signaling (Homo sapiens)
    - Ca2+ pathway (Homo sapiens)
      - Gbeta:gamma activation of PLC beta (Homo sapiens)

General

SBML | | PDF

SVG | | PPTX | SBGN

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

G beta:gamma engages the PH domain of Phospholipase C beta, stimulating phospholipase activity, resulting in increased PIP2 hydrolysis.

Literature References

PubMed ID	Title	Journal	Year
15611108	Regulatory interactions between the amino terminus of G-protein betagamma subunits and the catalytic domain of phospholipase Cbeta2 Bonacci, TM, Ghosh, M, Malik, S, Smrcka, AV	J Biol Chem	2005