Gbeta:gamma activation of PLC beta

Stable Identifier
R-HSA-398040
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
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Gbeta:gamma activation of PLC beta
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G beta:gamma engages the PH domain of Phospholipase C beta, stimulating phospholipase activity, resulting in increased PIP2 hydrolysis.

Literature References
PubMed ID Title Journal Year
15611108 Regulatory interactions between the amino terminus of G-protein betagamma subunits and the catalytic domain of phospholipase Cbeta2

Bonacci, TM, Ghosh, M, Malik, S, Smrcka, AV

J Biol Chem 2005
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Input
Output
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hasEvent
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Gbeta:gamma activation of PLC beta (Xenopus tropicalis)
Authored
Jupe, S  (2009-03-16)
Reviewed
Akkerman, JW  (2009-06-03)
Created
Jupe, S  (2009-03-16)