Reactome | Gbeta:gamma activation of PLC beta

Gbeta:gamma activation of PLC beta

Stable Identifier

R-HSA-398040

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol, plasma membrane

ReviewStatus

5/5

Locations in the PathwayBrowser

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Signal Transduction (Homo sapiens)

- Signaling by GPCR (Homo sapiens)
  - GPCR downstream signalling (Homo sapiens)
    - G-protein beta:gamma signalling (Homo sapiens)
      - G beta:gamma signalling through PLC beta (Homo sapiens)
        
        Gbeta:gamma activation of PLC beta (Homo sapiens)
- Signaling by WNT (Homo sapiens)
  - Beta-catenin independent WNT signaling (Homo sapiens)
    - Ca2+ pathway (Homo sapiens)
      - Gbeta:gamma activation of PLC beta (Homo sapiens)

General

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G beta:gamma engages the PH domain of Phospholipase C beta, stimulating phospholipase activity, resulting in increased PIP2 hydrolysis.

Literature References

PubMed ID	Title	Journal	Year
15611108	Regulatory interactions between the amino terminus of G-protein betagamma subunits and the catalytic domain of phospholipase Cbeta2 Smrcka, AV, Bonacci, TM, Ghosh, M, Malik, S	J Biol Chem	2005