p-EFNB binds GRB4

Stable Identifier
R-HSA-3928639
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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Unlike EPH receptors, ephrinBs (EFNBs) do not possess intrinsic catalytic activity and thus rely on the recruitment of signaling molecules to signal. Phosphorylated ephrinB (p-EFNB) provides docking site for the SH2/SH3 domain-containing adapter protein cytoplasmic protein NCK2 (NCK2 aka GRB4) (Cowan & Henkemeyer 2001). GRB4 is able to bind to phosphotyrosines in EFNBs through their SH2 domains and 'PxxP' motifs through their SH3 domains. It has been postulated that GRB4 acts as a bridge between EFNBs and G protein-coupled receptor kinase interacting protein (GIT) 1 and Rac at synapses (Segura et al. 2007).

Literature References
PubMed ID Title Journal Year
11557983 The SH2/SH3 adaptor Grb4 transduces B-ephrin reverse signals

Cowan, CA, Henkemeyer, M

Nature 2001
17310244 Grb4 and GIT1 transduce ephrinB reverse signals modulating spine morphogenesis and synapse formation

Segura, I, Essmann, CL, Weinges, S, Acker-Palmer, A

Nat. Neurosci. 2007
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