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p-EFNB binds GRB4
Stable Identifier
R-HSA-3928639
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol
,
plasma membrane
ReviewStatus
5/5
Locations in the PathwayBrowser
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Developmental Biology (Homo sapiens)
Nervous system development (Homo sapiens)
Axon guidance (Homo sapiens)
EPH-Ephrin signaling (Homo sapiens)
Ephrin signaling (Homo sapiens)
p-EFNB binds GRB4 (Homo sapiens)
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Unlike EPH receptors, ephrinBs (EFNBs) do not possess intrinsic catalytic activity and thus rely on the recruitment of signaling molecules to signal. Phosphorylated ephrinB (p-EFNB) provides docking site for the SH2/SH3 domain-containing adapter protein cytoplasmic protein NCK2 (NCK2 aka GRB4) (Cowan & Henkemeyer 2001). GRB4 is able to bind to phosphotyrosines in EFNBs through their SH2 domains and 'PxxP' motifs through their SH3 domains. It has been postulated that GRB4 acts as a bridge between EFNBs and G protein-coupled receptor kinase interacting protein (GIT) 1 and Rac at synapses (Segura et al. 2007).
Literature References
PubMed ID
Title
Journal
Year
17310244
Grb4 and GIT1 transduce ephrinB reverse signals modulating spine morphogenesis and synapse formation
Acker-Palmer, A
,
Essmann, CL
,
Weinges, S
,
Segura, I
Nat. Neurosci.
2007
11557983
The SH2/SH3 adaptor Grb4 transduces B-ephrin reverse signals
Henkemeyer, M
,
Cowan, CA
Nature
2001
Participants
Input
EPHBs:p-3Y-EFNBs:SRC,FYN [plasma membrane]
(Homo sapiens)
NCK2 [cytosol]
(Homo sapiens)
Output
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4 [plasma membrane]
(Homo sapiens)
Entity On Other Cell
EPHBs [plasma membrane]
(Homo sapiens)
Participates
as an event of
Ephrin signaling (Homo sapiens)
Orthologous Events
p-EFNB binds GRB4 (Bos taurus)
p-EFNB binds GRB4 (Caenorhabditis elegans)
p-EFNB binds GRB4 (Canis familiaris)
p-EFNB binds GRB4 (Danio rerio)
p-EFNB binds GRB4 (Drosophila melanogaster)
p-EFNB binds GRB4 (Gallus gallus)
p-EFNB binds GRB4 (Mus musculus)
p-EFNB binds GRB4 (Rattus norvegicus)
p-EFNB binds GRB4 (Sus scrofa)
p-EFNB binds GRB4 (Xenopus tropicalis)
Authored
Garapati, P V (2013-07-23)
Reviewed
Ip, NY (2014-05-19)
Created
Garapati, P V (2013-07-22)
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