PAK1 autophosphorylates

Stable Identifier
R-HSA-3928620
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Autophosphorylation of serine/threonine-protein kinase PAK1 (PAK1) is required for complete activation. PAK1 is autophosphorylated at several sites, but serine 144 (S144) in the GTPase binding domain and threonine 423 (T423) in the activation loop are the two conserved sites that regulate catalytic activity. As a result, active PAK1 phosphorylates substrates like LIMK (LIM domain kinase) that are involved in remodelling of the actin cytoskeleton.

Literature References
PubMed ID Title Journal Year
11134074 Temporal and spatial distribution of activated Pak1 in fibroblasts

Sells, MA, Pfaff, A, Chernoff, J

J. Cell Biol. 2000
11804587 Pak1 kinase homodimers are autoinhibited in trans and dissociated upon activation by Cdc42 and Rac1

Parrini, MC, Lei, M, Harrison, SC, Mayer, BJ

Mol Cell 2002
Participants
Participates
Catalyst Activity

protein serine/threonine kinase activity of RAC1:GTP:PAK1 dimer:RAC1:GTP [plasma membrane]

Orthologous Events
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