Reactome | PAK1 autophosphorylates

PAK1 autophosphorylates

Stable Identifier

R-HSA-3928620

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, plasma membrane

ReviewStatus

5/5

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Autophosphorylation of serine/threonine-protein kinase PAK1 (PAK1) is required for complete activation. PAK1 is autophosphorylated at several sites, but serine 144 (S144) in the GTPase binding domain and threonine 423 (T423) in the activation loop are the two conserved sites that regulate catalytic activity. As a result, active PAK1 phosphorylates substrates like LIMK (LIM domain kinase) that are involved in remodelling of the actin cytoskeleton.

Literature References

PubMed ID	Title	Journal	Year
11804587	Pak1 kinase homodimers are autoinhibited in trans and dissociated upon activation by Cdc42 and Rac1 Parrini, MC, Lei, M, Harrison, SC, Mayer, BJ	Mol Cell	2002
11134074	Temporal and spatial distribution of activated Pak1 in fibroblasts Sells, MA, Pfaff, A, Chernoff, J	J. Cell Biol.	2000