Reactome | PAK1 binds RAC1:GTP

PAK1 binds RAC1:GTP

Stable Identifier

R-HSA-3928619

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane, cytosol

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Serine/threonine-protein kinase PAK1 (PAK1) exists as homodimer in a trans-inhibited conformation. PAK1 translocates from cytosol to plasma membrane and comes in close proximity to RAC1. The kinase inhibitory (KI) domain of one PAK1 molecule binds to the C-terminal catalytic domain of the other and inhibits catalytic activity. RAC1:GTP bind to the GBD domain of PAK1 thereby altering the conformation of the KI domain, relieving inhibition of its catalytic domain, and allowing PAK1 autophosphorylation that is required for full kinase activity (Parrini et al. 2002, Zhao & Manser 2005, Sells et al. 2000).

Literature References

PubMed ID	Title	Journal	Year
11804587	Pak1 kinase homodimers are autoinhibited in trans and dissociated upon activation by Cdc42 and Rac1 Parrini, MC, Lei, M, Harrison, SC, Mayer, BJ	Mol Cell	2002
15548136	PAK and other Rho-associated kinases--effectors with surprisingly diverse mechanisms of regulation Zhao, ZS, Manser, E	Biochem J	2005
11134074	Temporal and spatial distribution of activated Pak1 in fibroblasts Sells, MA, Pfaff, A, Chernoff, J	J. Cell Biol.	2000