N-WASP binds ITSN1

Stable Identifier
R-HSA-3928600
Type
Reaction [binding]
Species
Homo sapiens
Compartment
Synonyms
Activation of intersectin-1 by EPHB and N-WASP
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Neural Wiskott-Aldrich syndrome protein (N-WASP, WASL) with its extended proline-rich region binds simultaneously to several of the five SH3 domains of intersectin-1 (ITSN1). Double-label immunofluorescence confirmed the colocalization of ITSN1, N-WASP and EPHB2 in spines. N-WASP in cooperation with EPHB2 activates the GEF activity of intersectin-1 (Irie & Yamaguchi 2002).

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