N-WASP binds ITSN1

Stable Identifier
R-HSA-3928600
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane, cytosol
Synonyms
Activation of intersectin-1 by EPHB and N-WASP
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
N-WASP binds ITSN1
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Neural Wiskott-Aldrich syndrome protein (N-WASP, WASL) with its extended proline-rich region binds simultaneously to several of the five SH3 domains of intersectin-1 (ITSN1). Double-label immunofluorescence confirmed the colocalization of ITSN1, N-WASP and EPHB2 in spines. N-WASP in cooperation with EPHB2 activates the GEF activity of intersectin-1 (Irie & Yamaguchi 2002).

Participants
Input
Output
Entity On Other Cell
Participant Of
hasEvent
Inferred From
N-Wasp binds intersectin-1 (Mus musculus)
Authored
Garapati, P V  (2013-07-22)
Reviewed
Ip, NY  (2014-05-19)
Created
Garapati, P V  (2013-07-22)