N-WASP binds ITSN1

Stable Identifier
R-HSA-3928600
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane, cytosol
Synonyms
Activation of intersectin-1 by EPHB and N-WASP
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N-WASP binds ITSN1
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Neural Wiskott-Aldrich syndrome protein (N-WASP, WASL) with its extended proline-rich region binds simultaneously to several of the five SH3 domains of intersectin-1 (ITSN1). Double-label immunofluorescence confirmed the colocalization of ITSN1, N-WASP and EPHB2 in spines. N-WASP in cooperation with EPHB2 activates the GEF activity of intersectin-1 (Irie & Yamaguchi 2002).

Participants
Input
Output
Entity On Other Cell
Participant Of
hasEvent
Inferred From
N-Wasp binds intersectin-1 (Mus musculus)
Authored
Garapati, P V  (2013-07-23)
Reviewed
Ip, NY  (2014-05-19)
Created
Garapati, P V  (2013-07-22)
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