Reactome | Transport of L1 into endosomes

Transport of L1 into endosomes

Stable Identifier

R-HSA-392749

Type

Reaction [transition]

Species

Homo sapiens

Compartment

endosome

ReviewStatus

5/5

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Membrane bound L1 is internalized through clathrin coated vesicles and is endocytosed into recycling endosomes. Moreover, L1 promotes co-endocytosis of beta1 integrins with which it is associated into early endosomes.

Literature References

PubMed ID	Title	Journal	Year
9651214	The neural cell adhesion molecule L1 interacts with the AP-2 adaptor and is endocytosed via the clathrin-mediated pathway Kamiguchi, H, Long, KE, Pendergast, M, Schaefer, AW, Rapoport, I, Kirchhausen, T, Lemmon, V	J Neurosci	1998
10804209	Recycling of the cell adhesion molecule L1 in axonal growth cones Kamiguchi, H, Lemmon, V	J Neurosci	2000
16330023	Endocytosis of beta1 integrins is an early event in migration promoted by the cell adhesion molecule L1 Panicker, AK, Buhusi, M, Erickson, A, Maness, PF	Exp Cell Res	2006