p-S400-Cot phosphorylates NIK

Stable Identifier
R-HSA-392530
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Cot functions upstream of NIK in the CD28-costimulation signaling pathway leading to activation of NF-kB. Cot binds avidly to NIK and induces NIK phosphorylation in vivo.

Literature References
PubMed ID Title Journal Year
18439422 NIK and Cot cooperate to trigger NF-kappaB p65 phosphorylation

Schmitz, ML, Wittwer, T

Biochem Biophys Res Commun 2008
Participants
Participates
Catalyst Activity

MAP kinase kinase kinase activity of p-S400-MAP3K8 [cytosol]

Orthologous Events
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