p-S400-Cot phosphorylates NIK

Stable Identifier
R-HSA-392530
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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p-S400-Cot phosphorylates NIK
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COT (MAP3K8) phosphorylates NIK (NF-κB-inducing kinase), a key step in activating the non-canonical NF-κB signaling pathway. This phosphorylation enhances NIK's role in activating the IKKα complex, leading to the processing of NF-κB2 (p100) into its active form, p52 (Wittwer and Schmitz 2008).
Literature References
PubMed ID Title Journal Year
18439422 NIK and Cot cooperate to trigger NF-kappaB p65 phosphorylation

Schmitz, ML, Wittwer, T

Biochem Biophys Res Commun 2008
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Catalyst Activity

MAP kinase kinase kinase activity of p-S400-MAP3K8 [cytosol]

Physical Entity
p-S400-MAP3K8 [cytosol] (Homo sapiens)
Activity
MAP kinase kinase kinase activity (GO:0004709)
Orthologous Events
p-S400-Cot phosphorylates NIK (Bos taurus)
p-S400-Cot phosphorylates NIK (Canis familiaris)
p-S400-Cot phosphorylates NIK (Gallus gallus)
p-S400-Cot phosphorylates NIK (Mus musculus)
p-S400-Cot phosphorylates NIK (Rattus norvegicus)
p-S400-Cot phosphorylates NIK (Saccharomyces cerevisiae)
p-S400-Cot phosphorylates NIK (Sus scrofa)
p-S400-Cot phosphorylates NIK (Xenopus tropicalis)
Authored
Garapati, P V  (2008-12-16)
Reviewed
Bluestone, JA  (2009-06-01)
Esensten, J  (2009-06-01)
Created
Garapati, P V  (2009-03-05)
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