BLT receptors can bind LTB4

Stable Identifier
Reaction [binding]
Homo sapiens
Locations in the PathwayBrowser
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

The dihydroxy-leukotriene, leukotriene B4 (LTB4) stimulates neutrophil chemotaxis and secretion. Chemotaxis, the principal effects of LTB4 and related dihydroxy-acids on leukocytes, occurs via activation of BLT (1 and 2) receptors (Yokomizo T et al, 1997; Yokozimo T et al, 2000). BLT2 is expressed ubiquitously, in contrast to BLT1, which is expressed predominantly in leukocytes. These receptors mediate their actions by coupling to G protein alpha q/11 subunits (McLeish KR et al, 1989) which activate a phosphatidylinositol-calcium second messenger system.

Literature References
PubMed ID Title Journal Year
10934230 A second leukotriene B(4) receptor, BLT2. A new therapeutic target in inflammation and immunological disorders

Kato, K, Yokomizo, T, Izumi, T, Shimizu, T, Terawaki, K

J Exp Med 2000
9177352 A G-protein-coupled receptor for leukotriene B4 that mediates chemotaxis

Takuwa, Y, Yokomizo, T, Chang, K, Izumi, T, Shimizu, T

Nature 1997
2548477 Evidence that activation of a common G-protein by receptors for leukotriene B4 and N-formylmethionyl-leucyl-phenylalanine in HL-60 cells occurs by different mechanisms

Gierschik, P, Sidiropoulos, D, Schepers, T, Jakobs, KH, McLeish, KR

Biochem J 1989
Orthologous Events
Cite Us!