Reactome | BLT receptors can bind LTB4

BLT receptors can bind LTB4

Stable Identifier

R-HSA-391941

Type

Reaction [binding]

Species

Homo sapiens

Compartment

extracellular region, plasma membrane

ReviewStatus

5/5

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Signal Transduction (Homo sapiens)

- Signaling by GPCR (Homo sapiens)
  - GPCR ligand binding (Homo sapiens)
    - Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
      - Eicosanoid ligand-binding receptors (Homo sapiens)
        
        Leukotriene receptors (Homo sapiens)
        
        BLT receptors can bind LTB4 (Homo sapiens)

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The dihydroxy-leukotriene, leukotriene B4 (LTB4) stimulates neutrophil chemotaxis and secretion. Chemotaxis, the principal effects of LTB4 and related dihydroxy-acids on leukocytes, occurs via activation of BLT (1 and 2) receptors (Yokomizo T et al, 1997; Yokozimo T et al, 2000). BLT2 is expressed ubiquitously, in contrast to BLT1, which is expressed predominantly in leukocytes. These receptors mediate their actions by coupling to G protein alpha q/11 subunits (McLeish KR et al, 1989) which activate a phosphatidylinositol-calcium second messenger system.

Literature References

PubMed ID	Title	Journal	Year
10934230	A second leukotriene B(4) receptor, BLT2. A new therapeutic target in inflammation and immunological disorders Yokomizo, T, Kato, K, Terawaki, K, Izumi, T, Shimizu, T	J Exp Med	2000
9177352	A G-protein-coupled receptor for leukotriene B4 that mediates chemotaxis Yokomizo, T, Izumi, T, Chang, K, Takuwa, Y, Shimizu, T	Nature	1997
2548477	Evidence that activation of a common G-protein by receptors for leukotriene B4 and N-formylmethionyl-leucyl-phenylalanine in HL-60 cells occurs by different mechanisms McLeish, KR, Gierschik, P, Schepers, T, Sidiropoulos, D, Jakobs, KH	Biochem J	1989