BLT receptors can bind LTB4

Stable Identifier
R-HSA-391941
Type
Reaction [binding]
Species
Homo sapiens
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The dihydroxy-leukotriene, leukotriene B4 (LTB4) stimulates neutrophil chemotaxis and secretion. Chemotaxis, the principal effects of LTB4 and related dihydroxy-acids on leukocytes, occurs via activation of BLT (1 and 2) receptors (Yokomizo T et al, 1997; Yokozimo T et al, 2000). BLT2 is expressed ubiquitously, in contrast to BLT1, which is expressed predominantly in leukocytes. These receptors mediate their actions by coupling to G protein alpha q/11 subunits (McLeish KR et al, 1989) which activate a phosphatidylinositol-calcium second messenger system.

Literature References
PubMed ID Title Journal Year
9177352 A G-protein-coupled receptor for leukotriene B4 that mediates chemotaxis

Yokomizo, T, Izumi, T, Chang, K, Takuwa, Y, Shimizu, T

Nature 1997
10934230 A second leukotriene B(4) receptor, BLT2. A new therapeutic target in inflammation and immunological disorders

Yokomizo, T, Kato, K, Terawaki, K, Izumi, T, Shimizu, T

J Exp Med 2000
2548477 Evidence that activation of a common G-protein by receptors for leukotriene B4 and N-formylmethionyl-leucyl-phenylalanine in HL-60 cells occurs by different mechanisms

McLeish, KR, Gierschik, P, Schepers, T, Sidiropoulos, D, Jakobs, KH

Biochem J 1989
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