Reactome | EP1 receptor can bind PGE2

EP1 receptor can bind PGE2

Stable Identifier

R-HSA-391936

Type

Reaction [binding]

Species

Homo sapiens

Compartment

extracellular region, plasma membrane

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

Signal Transduction (Homo sapiens)

- Signaling by GPCR (Homo sapiens)
  - GPCR ligand binding (Homo sapiens)
    - Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
      - Eicosanoid ligand-binding receptors (Homo sapiens)
        
        Prostanoid ligand receptors (Homo sapiens)
        
        EP1 receptor can bind PGE2 (Homo sapiens)

General

SBML | | PDF

SVG | | PPTX | SBGN

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

The EP1 protein (Funk CD et al, 1993) is one of four receptors identified for prostaglandin E2 (PGE2). The effects of PGE2 are mediated through the G protein g alpha q/11 subunits and the subsequent phosphatidylinositol-calcium second messenger system (Funk CD et al, 1993).

Literature References

PubMed ID	Title	Journal	Year
8253813	Cloning and expression of a cDNA for the human prostaglandin E receptor EP1 subtype Funk, CD, Furci, L, FitzGerald, GA, Grygorczyk, R, Rochette, C, Bayne, MA, Abramovitz, M, Adam, M, Metters, KM	J Biol Chem	1993