EP3 receptor can bind PGE2

Stable Identifier
Reaction [binding]
Homo sapiens
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EP3 receptor mRNA are subject to alternative splicing at their 3'-ends and, to date, six expressed protein isoforms have been found in man (Yang J et al, 1994; Schmid A et al, 1995). These isoforms (not annotated here) differ in their G-protein coupling thereby contributing to the wide spectrum of EP3 actions: contraction of smooth muscle, enhancement of platelet aggregation, inhibition of autonomic neurotransmitter release, inhibition of gastric acid secretion, and inhibition of fat cell lipolysis.

Literature References
PubMed ID Title Journal Year
8117308 Cloning and expression of the EP3-subtype of human receptors for prostaglandin E2

Xia, M, An, S, Goetzl, EJ, Yang, J

Biochem Biophys Res Commun 1994
7532011 Differential activation of Gi and Gs proteins by E- and I-type prostaglandins in membranes from the human erythroleukaemia cell line, HEL

Schultz, G, Offermanns, S, Spicher, K, Seifert, R, Schwaner, I

Biochim Biophys Acta 1995
7883006 Splice variants of the human EP3 receptor for prostaglandin E2

Dinter, H, Thierauch, KH, Schleuning, WD, Schmid, A

Eur J Biochem 1995
Orthologous Events
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