Reactome | EP3 receptor can bind PGE2

EP3 receptor can bind PGE2

Stable Identifier

R-HSA-391933

Type

Reaction [binding]

Species

Homo sapiens

Compartment

extracellular region, plasma membrane

ReviewStatus

5/5

Locations in the PathwayBrowser

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Signal Transduction (Homo sapiens)

- Signaling by GPCR (Homo sapiens)
  - GPCR ligand binding (Homo sapiens)
    - Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
      - Eicosanoid ligand-binding receptors (Homo sapiens)
        
        Prostanoid ligand receptors (Homo sapiens)
        
        EP3 receptor can bind PGE2 (Homo sapiens)

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EP3 receptor mRNA are subject to alternative splicing at their 3'-ends and, to date, six expressed protein isoforms have been found in man (Yang J et al, 1994; Schmid A et al, 1995). These isoforms (not annotated here) differ in their G-protein coupling thereby contributing to the wide spectrum of EP3 actions: contraction of smooth muscle, enhancement of platelet aggregation, inhibition of autonomic neurotransmitter release, inhibition of gastric acid secretion, and inhibition of fat cell lipolysis.

Literature References

PubMed ID	Title	Journal	Year
8117308	Cloning and expression of the EP3-subtype of human receptors for prostaglandin E2 Xia, M, An, S, Goetzl, EJ, Yang, J	Biochem Biophys Res Commun	1994
7532011	Differential activation of Gi and Gs proteins by E- and I-type prostaglandins in membranes from the human erythroleukaemia cell line, HEL Schultz, G, Offermanns, S, Spicher, K, Seifert, R, Schwaner, I	Biochim Biophys Acta	1995
7883006	Splice variants of the human EP3 receptor for prostaglandin E2 Dinter, H, Thierauch, KH, Schleuning, WD, Schmid, A	Eur J Biochem	1995