Reactome | Oxoeicosanoid receptor can bind oxoeicosanoid

Oxoeicosanoid receptor can bind oxoeicosanoid

Stable Identifier

R-HSA-391905

Type

Reaction [binding]

Species

Homo sapiens

Compartment

extracellular region, plasma membrane

ReviewStatus

5/5

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Oxoeicosanoid receptor can bind oxoeicosanoid

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Oxoeicosanoids are a family of biologically active arachidonic acid derivatives that are associated with cellular migration. These mediators are potent chemotaxins for eosinophils, monocytes and polymorphonuclear neutrophils. They act via the OXE receptor (Hosoi T et al, 2002), expressed principally in kidney, liver as well as in eosinophils, neutrophils, and lung macrophages. The most potent ligand is 5-oxo-6,8,11,14-eicosatetraenoic acid (5-oxo-ETE). Activation of the receptor leads to calcium mobilization and the receptor was shown to be coupled to the G alpha i subunit (Jones CE et al, 2003).

Literature References

PubMed ID	Title	Journal	Year
12065583	Identification of a novel human eicosanoid receptor coupled to G(i/o) Hosoi, T, Koguchi, Y, Sugikawa, E, Chikada, A, Ogawa, K, Tsuda, N, Suto, N, Tsunoda, S, Taniguchi, T, Ohnuki, T	J Biol Chem	2002
12606753	Expression and characterization of a 5-oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid receptor highly expressed on human eosinophils and neutrophils Jones, CE, Holden, S, Tenaillon, L, Bhatia, U, Seuwen, K, Tranter, P, Turner, J, Kettle, R, Bouhelal, R, Charlton, S, Nirmala, NR, Jarai, G, Finan, P	Mol Pharmacol	2003