Reactome | TAAR8 [plasma membrane]

TAAR8 [plasma membrane]

Stable Identifier

R-HSA-391199

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

RecName: Full=Trace amine-associated receptor 8; AltName: Full=Trace amine receptor 5; Short=TaR-5; AltName: Full=G-protein coupled receptor 102; GN Name=TAAR8; Synonyms=GPR102, TA5, TAR5, TRAR5; OS Homo sapiens, TAAR8_HUMAN

Locations in the PathwayBrowser

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Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - Leishmania infection (Homo sapiens)
    - Leishmania parasite growth and survival (Homo sapiens)
      - Anti-inflammatory response favouring Leishmania parasite infection (Homo sapiens)
        
        ADORA2B mediated anti-inflammatory cytokines production (Homo sapiens)
        
        ADORA2B (in Ade-Rib:ADORA2B:Heterotrimeric G-protein Gs) exchanges GDP for GTP on Gs (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gs:Heterotrimeric G-protein Gs (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
        
        Trace amine-associated receptor:PEA [plasma membrane] (Homo sapiens)
        
        Trace amine-associated receptor [plasma membrane] (Homo sapiens)
        
        TAAR8 [plasma membrane] (Homo sapiens)

Signal Transduction (Homo sapiens)

- Signaling by GPCR (Homo sapiens)
  - GPCR downstream signalling (Homo sapiens)
    - G alpha (s) signalling events (Homo sapiens)
      - Liganded Gs-activating GPCR acts as a GEF for Gs (Homo sapiens)
        
        GPCR:ligand complexes that act on Gs:Heterotrimeric G-protein Gs (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
        
        Trace amine-associated receptor:PEA [plasma membrane] (Homo sapiens)
        
        Trace amine-associated receptor [plasma membrane] (Homo sapiens)
        
        TAAR8 [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gs:Heterotrimeric G-protein Gs (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
        
        Trace amine-associated receptor:PEA [plasma membrane] (Homo sapiens)
        
        Trace amine-associated receptor [plasma membrane] (Homo sapiens)
        
        TAAR8 [plasma membrane] (Homo sapiens)
      - Liganded Gs-activating GPCRs bind inactive heterotrimeric Gs (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
        
        Trace amine-associated receptor:PEA [plasma membrane] (Homo sapiens)
        
        Trace amine-associated receptor [plasma membrane] (Homo sapiens)
        
        TAAR8 [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gs:Heterotrimeric G-protein Gs (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
        
        Trace amine-associated receptor:PEA [plasma membrane] (Homo sapiens)
        
        Trace amine-associated receptor [plasma membrane] (Homo sapiens)
        
        TAAR8 [plasma membrane] (Homo sapiens)
      - The Ligand:GPCR:Gs complex dissociates (Homo sapiens)
        
        GPCR:ligand complexes that act on Gs:Heterotrimeric G-protein Gs (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
        
        Trace amine-associated receptor:PEA [plasma membrane] (Homo sapiens)
        
        Trace amine-associated receptor [plasma membrane] (Homo sapiens)
        
        TAAR8 [plasma membrane] (Homo sapiens)
        
        GPCRs that activate Gs [plasma membrane] (Homo sapiens)
        
        Trace amine-associated receptor [plasma membrane] (Homo sapiens)
        
        TAAR8 [plasma membrane] (Homo sapiens)
  - GPCR ligand binding (Homo sapiens)
    - Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
      - Amine ligand-binding receptors (Homo sapiens)
        
        Trace amine-associated receptors can bind trace amines (Homo sapiens)
        
        Trace amine-associated receptor [plasma membrane] (Homo sapiens)
        
        TAAR8 [plasma membrane] (Homo sapiens)
        
        Trace amine-associated receptor:PEA [plasma membrane] (Homo sapiens)
        
        Trace amine-associated receptor [plasma membrane] (Homo sapiens)
        
        TAAR8 [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q969N4 TAAR8

Gene Names

TAAR8, GPR102, TA5, TAR5, TRAR5

Chain

chain:1-342

Reference Genes

BioGPS Gene:83551 TAAR8

COSMIC (genes):TAAR8 TAAR8

CTD Gene:83551 TAAR8

dbSNP Gene:83551 TAAR8

ENSEMBL:ENSG00000146385 TAAR8

HGNC:14964 TAAR8

KEGG Gene (Homo sapiens):83551 TAAR8

Monarch:83551 TAAR8

NCBI Gene:83551 TAAR8

OMIM:606927 TAAR8

UCSC:Q969N4 TAAR8

Reference Transcript

RefSeq:NM_053278.2 TAAR8

Other Identifiers

0000610338

11743211_at

1553552_at

17012692

2926138

2926139

2926140

2926141

2926142

8122129

83551

A_14_P113930

A_23_P8269

GE473849

GO:0001594

GO:0003674

GO:0004930

GO:0005575

GO:0005886

GO:0007165

GO:0007186

GO:0008150

GO:0016020

GO:0016021

HMNXSV003041854

Hs2.350571.1.S1_3p_at

ILMN_1772523

PH_hs_0032780

TC06000993.hg

Participates

as a candidate of

Trace amine-associated receptor [plasma membrane] (Homo sapiens)

Inferred To

taar18e [plasma membrane] (Danio rerio)

taar19h [plasma membrane] (Danio rerio)

taar12j [plasma membrane] (Danio rerio)

taar20v [plasma membrane] (Danio rerio)

si:ch211-139n6.11 [plasma membrane] (Danio rerio)

taar14j [plasma membrane] (Danio rerio)

taar19b [plasma membrane] (Danio rerio)

taar14e [plasma membrane] (Danio rerio)

si:ch211-238p8.35 [plasma membrane] (Danio rerio)

taar19m [plasma membrane] (Danio rerio)

taar20q [plasma membrane] (Danio rerio)

taar20c1 [plasma membrane] (Danio rerio)

taar18j [plasma membrane] (Danio rerio)

taar17a [plasma membrane] (Danio rerio)

taar18d [plasma membrane] (Danio rerio)

taar13a [plasma membrane] (Danio rerio)

taar19a [plasma membrane] (Danio rerio)

taar14d [plasma membrane] (Danio rerio)

taar19o [plasma membrane] (Danio rerio)

si:ch211-238p8.10 [plasma membrane] (Danio rerio)

taar3p [plasma membrane] (Xenopus tropicalis)

taar13c [plasma membrane] (Danio rerio)

taar20o [plasma membrane] (Danio rerio)

Taar8b [plasma membrane] (Mus musculus)

mAChR-C [plasma membrane] (Drosophila melanogaster)

LOC110438873 [plasma membrane] (Danio rerio)

taar12h [plasma membrane] (Danio rerio)

taar12c [plasma membrane] (Danio rerio)

taar20w [plasma membrane] (Danio rerio)

si:ch211-238p8.18 [plasma membrane] (Danio rerio)

taar20i [plasma membrane] (Danio rerio)

LOC110438874 [plasma membrane] (Danio rerio)

taar19c [plasma membrane] (Danio rerio)

si:ch211-238p8.31 [plasma membrane] (Danio rerio)

taar14h [plasma membrane] (Danio rerio)

taar20c [plasma membrane] (Danio rerio)

Taar8a [plasma membrane] (Rattus norvegicus)

taar13b [plasma membrane] (Danio rerio)

taar12b [plasma membrane] (Danio rerio)

taar12i [plasma membrane] (Danio rerio)

taar18c [plasma membrane] (Danio rerio)

taar19i [plasma membrane] (Danio rerio)

taar19u [plasma membrane] (Danio rerio)

taar18i [plasma membrane] (Danio rerio)

taar20p [plasma membrane] (Danio rerio)

taar16b [plasma membrane] (Danio rerio)

taar20h [plasma membrane] (Danio rerio)

si:dkey-181m19.17 [plasma membrane] (Danio rerio)

taar14b [plasma membrane] (Danio rerio)

taar19p [plasma membrane] (Danio rerio)

taar19k [plasma membrane] (Danio rerio)

taar18b [plasma membrane] (Danio rerio)

taar18h [plasma membrane] (Danio rerio)

taar19e [plasma membrane] (Danio rerio)

LOC110437881 [plasma membrane] (Danio rerio)

taar14a [plasma membrane] (Danio rerio)

taar15 [plasma membrane] (Danio rerio)

taar20t [plasma membrane] (Danio rerio)

taar16g [plasma membrane] (Danio rerio)

taar19q [plasma membrane] (Danio rerio)

taar20d1 [plasma membrane] (Danio rerio)

taar20x [plasma membrane] (Danio rerio)

taar18g [plasma membrane] (Danio rerio)

taar19j [plasma membrane] (Danio rerio)

taar20n [plasma membrane] (Danio rerio)

taar14g [plasma membrane] (Danio rerio)

taar12a [plasma membrane] (Danio rerio)

taar19d [plasma membrane] (Danio rerio)

TAAR8 [plasma membrane] (Danio rerio)

TAAR8 [plasma membrane] (Xenopus tropicalis)

taar18a [plasma membrane] (Danio rerio)

LOC110438872 [plasma membrane] (Danio rerio)

taar12g [plasma membrane] (Danio rerio)

taar13d [plasma membrane] (Danio rerio)

taar16a [plasma membrane] (Danio rerio)

taar20b [plasma membrane] (Danio rerio)

taar16f [plasma membrane] (Danio rerio)

taar20a [plasma membrane] (Danio rerio)

taar20r [plasma membrane] (Danio rerio)

taar14f [plasma membrane] (Danio rerio)

LOC516101 [plasma membrane] (Bos taurus)

taar12f [plasma membrane] (Danio rerio)

si:ch211-139n6.10 [plasma membrane] (Danio rerio)

taar20a1 [plasma membrane] (Danio rerio)

taar20f [plasma membrane] (Danio rerio)

taar20z [plasma membrane] (Danio rerio)

taar12e [plasma membrane] (Danio rerio)

taar13e [plasma membrane] (Danio rerio)

Homologues of TAAR8 [plasma membrane] (Danio rerio)

Homologues of TAAR8 [plasma membrane] (Xenopus tropicalis)

taar20g [plasma membrane] (Danio rerio)

si:dkey-246e3.4 [plasma membrane] (Danio rerio)

si:ch211-238p8.24 [plasma membrane] (Danio rerio)

taar14l [plasma membrane] (Danio rerio)

taar18f [plasma membrane] (Danio rerio)

taar19l [plasma membrane] (Danio rerio)

Cross References

RefSeq

NP_444508.1

Guide to Pharmacology - Targets

172

OpenTargets

ENSG00000146385

HPA

ENSG00000146385-TAAR8

GeneCards

Q969N4

Ensembl

ENST00000275200, ENSP00000275200, ENSG00000146385

PRO

Q969N4

Pharos - Targets

Q969N4

GlyGen

Q969N4

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