Phosphorylation of ITIM motif in SIRP alpha

Stable Identifier
R-HSA-391156
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
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Phosphorylation of ITIM motif in SIRP alpha
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Various growth factors and events such as integrin-mediated cell adhesion to extracellular matrix (ECM) proteins induce the tyrosine phosphorylation of SIRP alpha. The cytoplasmic tail of SIRP alpha has two ITIMs with four tyrosine residues that are potential sites for phosphorylation. Phosphorylation is not dependent on CD47 engagement but the presence of CD47 may enhance the effect. Src family kinases may be involved in the phosphorylation.

Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
protein tyrosine kinase activity of SRC-1, PTK2 [cytosol]
Physical Entity
SRC-1, PTK2 [cytosol]
Activity
protein tyrosine kinase activity (0004713)
Inferred From
Phosphorylation of ITIM in SIRP alpha (Rattus norvegicus)
Phosphorylation of ITIM in SIRP alpha (Mus musculus)
Authored
Garapati, P V  (2009-02-12)
Reviewed
Barclay, AN  (2010-05-20)
Created
Garapati, P V  (2009-02-12)