Reactome | HTR1B [plasma membrane]

HTR1B [plasma membrane]

Stable Identifier

R-HSA-390934

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

5-HT1B receptor, RecName: Full=5-hydroxytryptamine receptor 1B; AltName: Full=5-HT-1D-beta; Short=5-HT-1B; Short=5-HT1B; AltName: Full=Serotonin receptor 1B; AltName: Full=Serotonin 1D beta receptor; AltName: Full=S12;
GN Name=HTR1B; Synonyms=HTR1DB;
OS Homo sapiens, 5HT1B_HUMAN

Locations in the PathwayBrowser

Expand all

Signal Transduction (Homo sapiens)

- Signaling by GPCR (Homo sapiens)
  - GPCR downstream signalling (Homo sapiens)
    - G alpha (i) signalling events (Homo sapiens)
      - Liganded Gi-activating GPCR acts as a GEF for Gi (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        HTR1B,D,E,F,HTR5A:5HT [plasma membrane] (Homo sapiens)
        
        HTR1B,D,E,F,HTR5A [plasma membrane] (Homo sapiens)
        
        HTR1B [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        HTR1B,D,E,F,HTR5A:5HT [plasma membrane] (Homo sapiens)
        
        HTR1B,D,E,F,HTR5A [plasma membrane] (Homo sapiens)
        
        HTR1B [plasma membrane] (Homo sapiens)
      - Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        HTR1B,D,E,F,HTR5A:5HT [plasma membrane] (Homo sapiens)
        
        HTR1B,D,E,F,HTR5A [plasma membrane] (Homo sapiens)
        
        HTR1B [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        HTR1B,D,E,F,HTR5A:5HT [plasma membrane] (Homo sapiens)
        
        HTR1B,D,E,F,HTR5A [plasma membrane] (Homo sapiens)
        
        HTR1B [plasma membrane] (Homo sapiens)
      - The Ligand:GPCR:Gi complex dissociates (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        HTR1B,D,E,F,HTR5A:5HT [plasma membrane] (Homo sapiens)
        
        HTR1B,D,E,F,HTR5A [plasma membrane] (Homo sapiens)
        
        HTR1B [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        HTR1B,D,E,F,HTR5A:5HT [plasma membrane] (Homo sapiens)
        
        HTR1B,D,E,F,HTR5A [plasma membrane] (Homo sapiens)
        
        HTR1B [plasma membrane] (Homo sapiens)
  - GPCR ligand binding (Homo sapiens)
    - Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
      - Amine ligand-binding receptors (Homo sapiens)
        
        Serotonin receptors (Homo sapiens)
        
        HTR1 and 5A receptors can bind serotonin (Homo sapiens)
        
        HTR1B,D,E,F,HTR5A [plasma membrane] (Homo sapiens)
        
        HTR1B [plasma membrane] (Homo sapiens)
        
        HTR1B,D,E,F,HTR5A:5HT [plasma membrane] (Homo sapiens)
        
        HTR1B,D,E,F,HTR5A [plasma membrane] (Homo sapiens)
        
        HTR1B [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:P28222 HTR1B

Gene Names

HTR1B, HTR1DB

Chain

chain:1-390

Reference Genes

BioGPS Gene:3351 HTR1B

COSMIC (genes):HTR1B HTR1B

CTD Gene:3351 HTR1B

dbSNP Gene:3351 HTR1B

ENSEMBL:ENSG00000135312 HTR1B

HGNC:5287 HTR1B

KEGG:hsa:3351 HTR1B

Monarch:3351 HTR1B

NCBI Gene:3351 HTR1B

OMIM:182131 HTR1B

UCSC:P28222 HTR1B

Reference Transcript

RefSeq:NM_000863.2 HTR1B

Other Identifiers

11740407_at

17020995

210799_PM_at

210799_at

2961644

2961646

2961648

2961649

2961650

2961651

2961652

3351

35503_at

775_at

8127692

ADDON002416.hg

A_23_P156824

D10995_at

GE58094

GO:0001586

GO:0003013

GO:0004930

GO:0004993

GO:0005215

GO:0005515

GO:0005737

GO:0005783

GO:0005886

GO:0007186

GO:0007187

GO:0007193

GO:0007198

GO:0007208

GO:0007268

GO:0007631

GO:0014053

GO:0014059

GO:0014063

GO:0016020

GO:0023052

GO:0030425

GO:0030594

GO:0032229

GO:0042220

GO:0042310

GO:0042734

GO:0042756

GO:0043226

GO:0044305

GO:0045471

GO:0046849

GO:0050795

GO:0051378

GO:0051385

GO:0051967

GO:0060089

GO:0071312

GO:0071466

GO:0098666

GO:0099154

GO:0099171

GO:0099509

GO:0099589

GO:0099626

GO:1901363

GO:1904707

GO:2000300

HMNXSV003028484

ILMN_1814206

PH_hs_0031595

TC06001892.hg

g338025_3p_at

Participates

as a member of

HTR1B,D,E,F,HTR5A [plasma membrane] (Homo sapiens)

Inferred To

htr1b [plasma membrane] (Danio rerio)

octr-1 [plasma membrane] (Caenorhabditis elegans)

HTR1B [plasma membrane] (Bos taurus)

HTR1B [plasma membrane] (Canis familiaris)

HTR1B [plasma membrane] (Gallus gallus)

HTR1B [plasma membrane] (Mus musculus)

HTR1B [plasma membrane] (Rattus norvegicus)

HTR1B [plasma membrane] (Sus scrofa)

Cross References

RefSeq

NP_000854.1

Guide to Pharmacology - Targets

ENSEMBL

ENST00000369947, ENSP00000358963, ENSG00000135312

OpenTargets

ENSG00000135312

ZINC - FDA approved

5HT1B_HUMAN

ZINC - Substances

5HT1B_HUMAN

ZINC - Biogenic

5HT1B_HUMAN

ZINC target

P28222

PRO

P28222

PDB

4IAR, 7C61, 4IAQ, 6G79, 5V54

ZINC - Investigational

5HT1B_HUMAN

ZINC - Metabolites

5HT1B_HUMAN

GeneCards

HTR1B

HPA

ENSG00000135312-HTR1B

Pharos - Targets

P28222

ZINC - Predictions - Purchasable

5HT1B_HUMAN

HMDB Protein

HMDBP02400

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