Dopamine receptors 1 (Dearry A et al, 1990) and 5 (Sunahara RK et al, 1991) are members of the D1-like dopamine receptor family. Once activated, they couple to the G protein alpha-s subtype which can activate adenylate cyclase. This increases the intracellular concentration of cAMP, which, in neurons, is typically excitatory.
Seeman, P, George, SR, Ng, G, Sunahara, RK, Van Tol, HH, Niznik, HB, O'Dowd, BF, Torchia, J, Laurier, LG, Guan, HC
Falardeau, P, Caron, MG, Gingrich, JA, Dearry, A, Fremeau RT, Jr, Bates, MD
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