D1-like dopamine receptors bind to dopamine

Stable Identifier
R-HSA-390835
Type
Reaction
Species
Homo sapiens
Compartment
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Summation

Dopamine receptors 1 (Dearry A et al, 1990) and 5 (Sunahara RK et al, 1991) are members of the D1-like dopamine receptor family. Once activated, they couple to the G protein alpha-s subtype which can activate adenylate cyclase. This increases the intracellular concentration of cAMP, which, in neurons, is typically excitatory.

Literature References
PubMed ID Title Journal Year
2144334 Molecular cloning and expression of the gene for a human D1 dopamine receptor

Dearry, A, Gingrich, JA, Falardeau, P, Fremeau RT, Jr, Bates, MD, Caron, MG

Nature 1990
1826762 Cloning of the gene for a human dopamine D5 receptor with higher affinity for dopamine than D1

Sunahara, RK, Guan, HC, O'Dowd, BF, Seeman, P, Laurier, LG, Ng, G, George, SR, Torchia, J, Van Tol, HH, Niznik, HB

Nature 1991
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