Reactome | D1-like dopamine receptors bind to dopamine

D1-like dopamine receptors bind to dopamine

Stable Identifier

R-HSA-390835

Type

Reaction

Species

Homo sapiens

Compartment

extracellular region, plasma membrane

Locations in the PathwayBrowser

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Signal Transduction (Homo sapiens)

- Signaling by GPCR (Homo sapiens)
  - GPCR ligand binding (Homo sapiens)
    - Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
      - Amine ligand-binding receptors (Homo sapiens)
        
        Dopamine receptors (Homo sapiens)
        
        D1-like dopamine receptors bind to dopamine (Homo sapiens)

Summation

Dopamine receptors 1 (Dearry A et al, 1990) and 5 (Sunahara RK et al, 1991) are members of the D1-like dopamine receptor family. Once activated, they couple to the G protein alpha-s subtype which can activate adenylate cyclase. This increases the intracellular concentration of cAMP, which, in neurons, is typically excitatory.

Literature References

PubMed ID	Title	Journal	Year
2144334	Molecular cloning and expression of the gene for a human D1 dopamine receptor Dearry, A, Gingrich, JA, Falardeau, P, Fremeau RT, Jr, Bates, MD, Caron, MG	Nature	1990
1826762	Cloning of the gene for a human dopamine D5 receptor with higher affinity for dopamine than D1 Sunahara, RK, Guan, HC, O'Dowd, BF, Seeman, P, Laurier, LG, Ng, G, George, SR, Torchia, J, Van Tol, HH, Niznik, HB	Nature	1991