Reactome | DRD1,5 bind DA

DRD1,5 bind DA

Stable Identifier

R-HSA-390835

Type

Reaction [binding]

Species

Homo sapiens

Compartment

extracellular region, plasma membrane

ReviewStatus

5/5

Locations in the PathwayBrowser

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Signal Transduction (Homo sapiens)

- Signaling by GPCR (Homo sapiens)
  - GPCR ligand binding (Homo sapiens)
    - Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
      - Amine ligand-binding receptors (Homo sapiens)
        
        Dopamine receptors (Homo sapiens)
        
        DRD1,5 bind DA (Homo sapiens)

General

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Dopamine receptors 1 (Dearry A et al, 1990) and 5 (Sunahara RK et al, 1991) are members of the D1-like dopamine receptor family. Once activated, they couple to the G protein alpha-s subtype which can activate adenylate cyclase. This increases the intracellular concentration of cAMP, which, in neurons, is typically excitatory.

Literature References

PubMed ID	Title	Journal	Year
1826762	Cloning of the gene for a human dopamine D5 receptor with higher affinity for dopamine than D1 Seeman, P, George, SR, Ng, G, Sunahara, RK, Van Tol, HH, Niznik, HB, O'Dowd, BF, Torchia, J, Laurier, LG, Guan, HC	Nature	1991
2144334	Molecular cloning and expression of the gene for a human D1 dopamine receptor Falardeau, P, Caron, MG, Gingrich, JA, Dearry, A, Fremeau RT, Jr, Bates, MD	Nature	1990