Reactome | p-S21-MYL5 [cytosol]

p-S21-MYL5 [cytosol]

Stable Identifier

R-HSA-390737

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Phosphorylated Myosin regulatory light chain 5

Locations in the PathwayBrowser

Expand all

Muscle contraction (Homo sapiens)

- Smooth Muscle Contraction (Homo sapiens)
  - ATP Hydrolysis By Myosin (Homo sapiens)
    - ADP:Calcium Bound Myosin Actin Complex [plasma membrane] (Homo sapiens)
      - ADP Bound Smooth Muscle Myosin Complex [cytosol] (Homo sapiens)
        
        Phosphorylated Smooth Muscle Myosin Light Chain [cytosol] (Homo sapiens)
        
        p-S21-MYL5 [cytosol] (Homo sapiens)
    - ATP Bound Smooth Muscle Myosin Complex [cytosol] (Homo sapiens)
      - Phosphorylated Smooth Muscle Myosin Light Chain [cytosol] (Homo sapiens)
        
        p-S21-MYL5 [cytosol] (Homo sapiens)
    - ATP:Calcium Bound Myosin Actin Complex [plasma membrane] (Homo sapiens)
      - ATP Bound Smooth Muscle Myosin Complex [cytosol] (Homo sapiens)
        
        Phosphorylated Smooth Muscle Myosin Light Chain [cytosol] (Homo sapiens)
        
        p-S21-MYL5 [cytosol] (Homo sapiens)
  - Calcium Binds Caldesmon (Homo sapiens)
    - Calcium Bound Myosin Actin Complex [plasma membrane] (Homo sapiens)
      - Phosphorylated Smooth Muscle Myosin Light Chain [cytosol] (Homo sapiens)
        
        p-S21-MYL5 [cytosol] (Homo sapiens)
    - Inactive Myosin Actin Contractile Complex [plasma membrane] (Homo sapiens)
      - Phosphorylated Smooth Muscle Myosin Light Chain [cytosol] (Homo sapiens)
        
        p-S21-MYL5 [cytosol] (Homo sapiens)
  - Myosin Binds ATP (Homo sapiens)
    - ATP:Calcium Bound Myosin Actin Complex [plasma membrane] (Homo sapiens)
      - ATP Bound Smooth Muscle Myosin Complex [cytosol] (Homo sapiens)
        
        Phosphorylated Smooth Muscle Myosin Light Chain [cytosol] (Homo sapiens)
        
        p-S21-MYL5 [cytosol] (Homo sapiens)
    - p-S CALD1-Calcium Bound Myosin Actin Complex [plasma membrane] (Homo sapiens)
      - Phosphorylated Smooth Muscle Myosin Light Chain [cytosol] (Homo sapiens)
        
        p-S21-MYL5 [cytosol] (Homo sapiens)
  - Phosphorylation of Smooth Muscle Myosin Light Chains (Homo sapiens)
    - Phosphorylated Smooth Muscle Myosin Light Chain [cytosol] (Homo sapiens)
      - p-S21-MYL5 [cytosol] (Homo sapiens)
  - Release Of ADP From Myosin (Homo sapiens)
    - ADP:Calcium Bound Myosin Actin Complex [plasma membrane] (Homo sapiens)
      - ADP Bound Smooth Muscle Myosin Complex [cytosol] (Homo sapiens)
        
        Phosphorylated Smooth Muscle Myosin Light Chain [cytosol] (Homo sapiens)
        
        p-S21-MYL5 [cytosol] (Homo sapiens)
    - Calcium Bound Myosin Actin Complex [plasma membrane] (Homo sapiens)
      - Phosphorylated Smooth Muscle Myosin Light Chain [cytosol] (Homo sapiens)
        
        p-S21-MYL5 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q02045 MYL5

Gene Names

MYL5

Chain

chain:1-173

Reference Genes

BioGPS Gene:4636 MYL5

COSMIC (genes):MYL5 MYL5

CTD Gene:4636 MYL5

dbSNP Gene:4636 MYL5

ENSEMBL:ENSG00000215375 MYL5

ENSEMBL_homo_sapiens_GENE:ENSG00000215375.7 MYL5

HGNC:7586 MYL5

KEGG Gene (Homo sapiens):4636 MYL5

Monarch:4636 MYL5

NCBI Gene:4636 MYL5

OMIM:160782 MYL5

UCSC:Q02045 MYL5

Reference Transcript

Other Identifiers

11755935_a_at

16963780

205145_PM_s_at

205145_s_at

2714199

2714201

2714202

2714203

2714204

2714205

2714206

2714208

2714211

2714213

2714214

2714216

2714217

2714220

2714224

2714225

40773_at

4636

8093386

A_14_P116059

A_14_P128801

A_23_P258018

GE79567

GE88848

GO:0003012

GO:0005198

GO:0005509

GO:0005737

GO:0005829

GO:0005856

GO:0005859

GO:0006937

GO:0008307

GO:0016459

GO:0043226

GO:0046872

HMNXSV003028063

ILMN_1746948

ILMN_2203588

L03785_at

PH_hs_0033210

TC04000012.hg

g4505304_3p_at

Participates

as a member of

Phosphorylated Smooth Muscle Myosin Light Chain [cytosol] (Homo sapiens)

Other forms of this molecule

MYL5 [cytosol]

Inferred To

phospho-MYL5 [cytosol] (Canis familiaris)

phospho-MYL5 [cytosol] (Sus scrofa)

phospho-p-S21-MYL5 [cytosol] (Caenorhabditis elegans)

phospho-p-S21-MYL5 [cytosol] (Drosophila melanogaster)

phospho-p-S21-MYL5 [cytosol] (Plasmodium falciparum)

phospho-p-S21-MYL5 [cytosol] (Saccharomyces cerevisiae)

phospho-p-S21-MYL5 [cytosol] (Schizosaccharomyces pombe)

Homologues of p-S21-MYL5 [cytosol] (Caenorhabditis elegans)

Homologues of p-S21-MYL5 [cytosol] (Drosophila melanogaster)

Homologues of p-S21-MYL5 [cytosol] (Plasmodium falciparum)

phospho-CT39356 [cytosol] (Drosophila melanogaster)

phospho-mlcR [cytosol] (Dictyostelium discoideum)

Modified Residues

Name

O-phospho-L-serine at 21

Coordinate

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Cross References

RefSeq

NP_002468.1, XP_016863736.1, XP_016863734.1, XP_016863737.1, XP_016863735.1

OpenTargets

ENSG00000215375

GeneCards

Q02045

HPA

ENSG00000215375-MYL5

Ensembl

ENSG00000215375, ENSP00000383023, ENST00000506838, ENSP00000425162, ENSP00000427153, ENST00000505477, ENST00000511290, ENST00000400159, ENSP00000423118

PRO

Q02045

Pharos - Targets

Q02045

HMDB Protein

HMDBP07823