M2 and M4 receptors bind acetylcholine

Stable Identifier
R-HSA-390673
Type
Reaction [binding]
Species
Homo sapiens
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M2 muscarinic receptors (Peralta EG et al, 1987) are located in the heart, where they act to slow the heart rate down to normal sinus rhythm after stimulatory actions of the sympathetic nervous system. This is achieved by slowing the speed of depolarization. M4 muscarinic receptors are expressed in the CNS (Peralta EG et al, 1987). Both receptors act via Gi proteins, causing a decrease in cAMP in the cell and generally leading to inhibitory-type effects (Bräuner-Osborne H and Brann MR, 1996).

Literature References
PubMed ID Title Journal Year
8925880 Pharmacology of muscarinic acetylcholine receptor subtypes (m1-m5): high throughput assays in mammalian cells

Brauner-Osborne, H, Brann, MR

Eur J Pharmacol 1996
3443095 Distinct primary structures, ligand-binding properties and tissue-specific expression of four human muscarinic acetylcholine receptors

Peralta, EG, Ashkenazi, A, Winslow, JW, Smith, DH, Ramachandran, J, Capon, DJ

EMBO J 1987
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