Reactome | CHRM2,4 bind acetylcholine

CHRM2,4 bind acetylcholine

Stable Identifier

R-HSA-390673

Type

Reaction [binding]

Species

Homo sapiens

Compartment

extracellular region, plasma membrane

ReviewStatus

5/5

Locations in the PathwayBrowser

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Signal Transduction (Homo sapiens)

- Signaling by GPCR (Homo sapiens)
  - GPCR ligand binding (Homo sapiens)
    - Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
      - Amine ligand-binding receptors (Homo sapiens)
        
        Muscarinic acetylcholine receptors (Homo sapiens)
        
        CHRM2,4 bind acetylcholine (Homo sapiens)

General

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M2 muscarinic receptors (Peralta EG et al, 1987) are located in the heart, where they act to slow the heart rate down to normal sinus rhythm after stimulatory actions of the sympathetic nervous system. This is achieved by slowing the speed of depolarization. M4 muscarinic receptors are expressed in the CNS (Peralta EG et al, 1987). Both receptors act via Gi proteins, causing a decrease in cAMP in the cell and generally leading to inhibitory-type effects (Bräuner-Osborne H and Brann MR, 1996).

Literature References

PubMed ID	Title	Journal	Year
3443095	Distinct primary structures, ligand-binding properties and tissue-specific expression of four human muscarinic acetylcholine receptors Peralta, EG, Ashkenazi, A, Winslow, JW, Smith, DH, Ramachandran, J, Capon, DJ	EMBO J	1987
8925880	Pharmacology of muscarinic acetylcholine receptor subtypes (m1-m5): high throughput assays in mammalian cells Brauner-Osborne, H, Brann, MR	Eur J Pharmacol	1996