Reactome | MYBPC2 [cytosol]

MYBPC2 [cytosol]

Stable Identifier

R-HSA-390557

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Myosin-binding protein C, fast-type, MYPC2_HUMAN

Locations in the PathwayBrowser

Expand all

Muscle contraction (Homo sapiens)

- Striated Muscle Contraction (Homo sapiens)
  - ATP Hydrolysis By Myosin (Homo sapiens)
    - ADP:Calcium Bound Sarcomere Protein Complex [cytosol] (Homo sapiens)
      - M Disk Complex [cytosol] (Homo sapiens)
        
        Myosin-binding protein C [cytosol] (Homo sapiens)
        
        MYBPC2 [cytosol] (Homo sapiens)
    - ATP:Calcium Bound Sarcomere Protein Complex [cytosol] (Homo sapiens)
      - M Disk Complex [cytosol] (Homo sapiens)
        
        Myosin-binding protein C [cytosol] (Homo sapiens)
        
        MYBPC2 [cytosol] (Homo sapiens)
  - Calcium Binds Troponin-C (Homo sapiens)
    - Calcium Bound Sarcomere Protein Complex [cytosol] (Homo sapiens)
      - M Disk Complex [cytosol] (Homo sapiens)
        
        Myosin-binding protein C [cytosol] (Homo sapiens)
        
        MYBPC2 [cytosol] (Homo sapiens)
    - Inactive Sarcomere Protein Complex [cytosol] (Homo sapiens)
      - M Disk Complex [cytosol] (Homo sapiens)
        
        Myosin-binding protein C [cytosol] (Homo sapiens)
        
        MYBPC2 [cytosol] (Homo sapiens)
  - Myosin Binds ATP (Homo sapiens)
    - ATP:Calcium Bound Sarcomere Protein Complex [cytosol] (Homo sapiens)
      - M Disk Complex [cytosol] (Homo sapiens)
        
        Myosin-binding protein C [cytosol] (Homo sapiens)
        
        MYBPC2 [cytosol] (Homo sapiens)
    - Calcium Bound Sarcomere Protein Complex [cytosol] (Homo sapiens)
      - M Disk Complex [cytosol] (Homo sapiens)
        
        Myosin-binding protein C [cytosol] (Homo sapiens)
        
        MYBPC2 [cytosol] (Homo sapiens)
  - Release Of ADP From Myosin (Homo sapiens)
    - ADP:Calcium Bound Sarcomere Protein Complex [cytosol] (Homo sapiens)
      - M Disk Complex [cytosol] (Homo sapiens)
        
        Myosin-binding protein C [cytosol] (Homo sapiens)
        
        MYBPC2 [cytosol] (Homo sapiens)
    - Calcium Bound Sarcomere Protein Complex [cytosol] (Homo sapiens)
      - M Disk Complex [cytosol] (Homo sapiens)
        
        Myosin-binding protein C [cytosol] (Homo sapiens)
        
        MYBPC2 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q14324 MYBPC2

Gene Names

MYBPC2, MYBPCF

Chain

chain:1-1141

Reference Genes

BioGPS Gene:4606 MYBPC2

COSMIC - genes:MYBPC2 MYBPC2

CTD Gene:4606 MYBPC2

dbSNP Gene:4606 MYBPC2

ENSEMBL:ENSG00000086967 MYBPC2

HGNC:7550 MYBPC2

KEGG:hsa:4606 MYBPC2

Monarch:4606 MYBPC2

NCBI Gene:4606 MYBPC2

OMIM:160793 MYBPC2

UCSC:Q14324 MYBPC2

Reference Transcript

RefSeq:NM_004533.4 MYBPC2

Other Identifiers

11729864_at

16864525

206394_PM_at

206394_at

37941_at

3839361

3839363

3839364

3839365

3839366

3839367

3839368

3839369

3839370

3839371

3839372

3839373

3839374

3839375

3839376

3839377

3839379

3839380

3839381

3839383

3839384

3839385

3839386

3839387

3839388

3839390

3839391

3839392

3839393

3839394

3839395

3839396

3839397

3839399

4606

8030677

A_14_P135810

A_23_P16262

A_33_P3257182

GE59982

GO:0003779

GO:0005198

GO:0005515

GO:0005829

GO:0007155

GO:0008092

GO:0008307

GO:0031430

GO:0032982

GO:0045214

HMNXSV003028356

ILMN_1799743

PH_hs_0004840

TC19000759.hg

X73113_at

g4758747_3p_at

Participates

as a member of

Myosin-binding protein C [cytosol] (Homo sapiens)

Inferred To

Mybpc2 [cytosol] (Mus musculus)

Mybpc2 [cytosol] (Rattus norvegicus)

MYBPC2 [cytosol] (Bos taurus)

MYBPC2 [cytosol] (Canis familiaris)

MYBPC2 [cytosol] (Sus scrofa)

mybpc2a [cytosol] (Danio rerio)

Cross References

RefSeq

NP_004524.3

ENSEMBL

ENST00000357701, ENSP00000350332, ENSG00000086967

OpenTargets

ENSG00000086967

GeneCards

MYBPC2

HPA

ENSG00000086967-MYBPC2

PRO

Q14324

Pharos - Targets

Q14324

GlyGen

Q14324

PDB

2EDK, 2E7C, 2EDN