Reactome | Conversion of glyoxylate to oxalate

Conversion of glyoxylate to oxalate

Stable Identifier

R-HSA-389862

Type

Reaction [transition]

Species

Homo sapiens

Compartment

peroxisomal matrix

Synonyms

glyoxylate + H2O + O2 => H(+) + H2O2 + oxalate

ReviewStatus

5/5

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Peroxisomal hydroxyacid oxidase 1 catalyzes the reaction of glyoxylate to form oxalate. The active form of the enzyme is associated with FMN and is a tetramer (Jones et al. 2000; Murray et al. 2008; Vignaud et al. 2007; Williams et al. 2000).

Literature References

PubMed ID	Title	Journal	Year
10777549	Identification and characterization of HAOX1, HAOX2, and HAOX3, three human peroxisomal 2-hydroxy acid oxidases Gould, SJ, Morrell, JC, Jones, JM	J Biol Chem	2000
18215067	Active site and loop 4 movements within human glycolate oxidase: implications for substrate specificity and drug design Holmes, RP, Murray, MS, Lowther, WT	Biochemistry	2008
17669354	Purification and characterization of recombinant human liver glycolate oxidase Pietrancosta, N, Rumsby, G, Vignaud, C, Lederer, F, Williams, EL	Arch Biochem Biophys	2007
10978532	Identification and expression of a cDNA for human glycolate oxidase Rumsby, G, Cregeen, DP, Williams, EL	Biochim Biophys Acta	2000