Reactome | Conversion of glyoxylate to oxalate

Conversion of glyoxylate to oxalate

Stable Identifier

R-HSA-389862

Type

Reaction [transition]

Species

Homo sapiens

Compartment

peroxisomal matrix

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Peroxisomal hydroxyacid oxidase 1 catalyzes the reaction of glyoxylate to form oxalate. The active form of the enzyme is associated with FMN and is a tetramer (Jones et al. 2000; Murray et al. 2008; Vignaud et al. 2007; Williams et al. 2000).

Literature References

PubMed ID	Title	Journal	Year
18215067	Active site and loop 4 movements within human glycolate oxidase: implications for substrate specificity and drug design Murray, MS, Holmes, RP, Lowther, WT	Biochemistry	2008
10777549	Identification and characterization of HAOX1, HAOX2, and HAOX3, three human peroxisomal 2-hydroxy acid oxidases Jones, JM, Morrell, JC, Gould, SJ	J Biol Chem	2000
17669354	Purification and characterization of recombinant human liver glycolate oxidase Vignaud, C, Pietrancosta, N, Williams, EL, Rumsby, G, Lederer, F	Arch Biochem Biophys	2007
10978532	Identification and expression of a cDNA for human glycolate oxidase Williams, EL, Cregeen, DP, Rumsby, G	Biochim Biophys Acta	2000