PMP34-mediated exchange of cytosolic ATP for peroxisomal AMP

Stable Identifier
R-HSA-389652
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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The peroxisomal membrane transport protein PMP34 mediates the exchange of adenine nucleotides between the cytosol and the peroxisomal matrix. The localization of PMP34 has been established by immunofluoresence studies (Wylin et al. 1998). The cloned human protein restores adenine nucleotide transport in yeast whose endogenous peroxisomal transporter has been disrupted, and has adenine nucleotide transport activity in reconstituted lipid vesicles in vitro (Visser et al. 2002), consistent with its hypothesized role in vivo (Wanders and Waterham 2006).

Literature References
PubMed ID Title Journal Year
12445829 Identification of human PMP34 as a peroxisomal ATP transporter

Visser, WF, van Roermund, CW, Waterham, HR, Wanders, RJ

Biochem Biophys Res Commun 2002
9874197 Identification and characterization of human PMP34, a protein closely related to the peroxisomal integral membrane protein PMP47 of Candida boidinii

Wylin, T, Baes, M, Brees, C, Mannaerts, GP, Fransen, M, Van Veldhoven, PP

Eur J Biochem 1998
16756494 Biochemistry of mammalian peroxisomes revisited

Wanders, RJ, Waterham, HR

Annu Rev Biochem 2006
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
adenine nucleotide transmembrane transporter activity of SLC25A17 [peroxisomal membrane]
Physical Entity
Activity
Orthologous Events
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