Galanin receptors can bind galanin

Stable Identifier
R-HSA-389026
Type
Reaction [binding]
Species
Homo sapiens
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Galanin is a 30-amino acid inhibitory neuropeptide encoded by the GAL gene (Schmidt WE et al, 1991; Bersani M et al, 1991). It is involved in a number of physiological processes such as regulation of food intake, metabolism and reproduction and regulation of neurotransmitter and hormone release. These actions are mediated via the galanin receptor which binds galanin. Three receptor subtypes exist; GALR1 (Habert-Ortoli E et al, 1994), GALR2 (Fathi Z et al, 1998; Kolakowski LF et al, 1998) and GALR3 (Smith KE et al, 1998; Kolakowski LF et al, 1998). These receptors are found throughtout the PNS, CNS and the endocrine system.

Literature References
PubMed ID Title Journal Year
9722565 Cloned human and rat galanin GALR3 receptors. Pharmacology and activation of G-protein inwardly rectifying K+ channels

Smith, KE, Walker, MW, Artymyshyn, R, Bard, J, Borowsky, B, Tamm, JA, Yao, WJ, Vaysse, PJ, Branchek, TA, Gerald, C, Jones, KA

J Biol Chem 1998
7524088 Molecular cloning of a functional human galanin receptor

Habert-Ortoli, E, Amiranoff, B, Loquet, I, Laburthe, M, Mayaux, JF

Proc Natl Acad Sci U S A 1994
1710578 Human galanin: primary structure and identification of two molecular forms

Bersani, M, Johnsen, AH, Højrup, P, Dunning, BE, Andreasen, JJ, Holst, JJ

FEBS Lett 1991
1722333 Isolation and primary structure of pituitary human galanin, a 30-residue nonamidated neuropeptide

Schmidt, WE, Kratzin, H, Eckart, K, Drevs, D, Mundkowski, G, Clemens, A, Katsoulis, S, Schäfer, H, Gallwitz, B, Creutzfeldt, W

Proc Natl Acad Sci U S A 1991
9832121 Molecular characterization and expression of cloned human galanin receptors GALR2 and GALR3

Kolakowski LF, Jr, O'Neill, GP, Howard, AD, Broussard, SR, Sullivan, KA, Feighner, SD, Sawzdargo, M, Nguyen, T, Kargman, S, Shiao, LL, Hreniuk, DL, Tan, CP, Evans, J, Abramovitz, M, Chateauneuf, A, Coulombe, N, Ng, G, Johnson, MP, Tharian, A, Khoshbouei, H, George, SR, Smith, RG, O'Dowd, BF

J Neurochem 1998
9685625 Molecular characterization, pharmacological properties and chromosomal localization of the human GALR2 galanin receptor

Fathi, Z, Battaglino, PM, Iben, LG, Li, H, Baker, E, Zhang, D, McGovern, R, Mahle, CD, Sutherland, GR, Iismaa, TP, Dickinson, KE, Zimanyi, IA

Brain Res Mol Brain Res 1998
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