Reactome | Galanin receptors can bind galanin

Galanin receptors can bind galanin

Stable Identifier

R-HSA-389026

Type

Reaction [binding]

Species

Homo sapiens

Compartment

extracellular region, plasma membrane

ReviewStatus

5/5

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Galanin is a 30-amino acid inhibitory neuropeptide encoded by the GAL gene (Schmidt WE et al, 1991; Bersani M et al, 1991). It is involved in a number of physiological processes such as regulation of food intake, metabolism and reproduction and regulation of neurotransmitter and hormone release. These actions are mediated via the galanin receptor which binds galanin. Three receptor subtypes exist; GALR1 (Habert-Ortoli E et al, 1994), GALR2 (Fathi Z et al, 1998; Kolakowski LF et al, 1998) and GALR3 (Smith KE et al, 1998; Kolakowski LF et al, 1998). These receptors are found throughtout the PNS, CNS and the endocrine system.

Literature References

PubMed ID	Title	Journal	Year
7524088	Molecular cloning of a functional human galanin receptor Habert-Ortoli, E, Amiranoff, B, Loquet, I, Laburthe, M, Mayaux, JF	Proc Natl Acad Sci U S A	1994
9722565	Cloned human and rat galanin GALR3 receptors. Pharmacology and activation of G-protein inwardly rectifying K+ channels Smith, KE, Walker, MW, Artymyshyn, R, Bard, J, Borowsky, B, Tamm, JA, Yao, WJ, Vaysse, PJ, Branchek, TA, Gerald, C, Jones, KA	J Biol Chem	1998
1710578	Human galanin: primary structure and identification of two molecular forms Bersani, M, Johnsen, AH, Højrup, P, Dunning, BE, Andreasen, JJ, Holst, JJ	FEBS Lett	1991
1722333	Isolation and primary structure of pituitary human galanin, a 30-residue nonamidated neuropeptide Schmidt, WE, Kratzin, H, Eckart, K, Drevs, D, Mundkowski, G, Clemens, A, Katsoulis, S, Schäfer, H, Gallwitz, B, Creutzfeldt, W	Proc Natl Acad Sci U S A	1991
9832121	Molecular characterization and expression of cloned human galanin receptors GALR2 and GALR3 Kolakowski LF, Jr, O'Neill, GP, Howard, AD, Broussard, SR, Sullivan, KA, Feighner, SD, Sawzdargo, M, Nguyen, T, Kargman, S, Shiao, LL, Hreniuk, DL, Tan, CP, Evans, J, Abramovitz, M, Chateauneuf, A, Coulombe, N, Ng, G, Johnson, MP, Tharian, A, Khoshbouei, H, George, SR, Smith, RG, O'Dowd, BF	J Neurochem	1998
9685625	Molecular characterization, pharmacological properties and chromosomal localization of the human GALR2 galanin receptor Fathi, Z, Battaglino, PM, Iben, LG, Li, H, Baker, E, Zhang, D, McGovern, R, Mahle, CD, Sutherland, GR, Iismaa, TP, Dickinson, KE, Zimanyi, IA	Brain Res Mol Brain Res	1998