Reactome | Neuropeptide Y receptors can bind neuropeptide Y-related peptides

Neuropeptide Y receptors can bind neuropeptide Y-related peptides

Stable Identifier

R-HSA-388863

Type

Reaction [binding]

Species

Homo sapiens

Compartment

extracellular region, plasma membrane

ReviewStatus

5/5

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Neuropeptide Y receptors can bind neuropeptide Y-related peptides

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At least four neuropeptide Y receptor subtypes each with specific affinities to neuropeptide Y peptides, serve as regulators of mucosal function, gastrointestinal motility and secretion. Four receptors have been characterized to date; NPY1R (Larhammar D et al, 1992), NPY2R (Gerald C et al, 1995), NPY4R (Bard JA et al, 1995) and NPY5R (Parker EM and Xia L, 1999).

Neuropeptide Y peptides are also implicated as mediators in the pathogenesis of many gastrointestinal disorders, including malabsorption, short gut, inflammatory bowel diseases, and forms of pancreatitis. The three peptides are neuropeptide Y (NPY) (Minth CD et al, 1984), peptide YY (PYY) (Tatemoto K et al, 1988) and pancreatic peptide (PP) (Boel E et al, 1984).

Although each peptide can bind to any of the four receptors, they each have preferred receptors. NPY binds preferentially to NPY1R, PYY to NYP2R and PP to NYP4R.

Literature References

PubMed ID	Title	Journal	Year
7592911	Cloning and functional expression of a human Y4 subtype receptor for pancreatic polypeptide, neuropeptide Y, and peptide YY Bard, JA, Walker, MW, Branchek, TA, Weinshank, RL	J Biol Chem	1995
6373251	A cDNA encoding a small common precursor for human pancreatic polypeptide and pancreatic icosapeptide Boel, E, Schwartz, TW, Norris, KE, Fiil, NP	EMBO J	1984
10461880	Extensive alternative splicing in the 5'-untranslated region of the rat and human neuropeptide Y Y5 receptor genes regulates receptor expression Parker, EM, Xia, L	J Neurochem	1999
1317848	Cloning and functional expression of a human neuropeptide Y/peptide YY receptor of the Y1 type Larhammar, D, Blomqvist, AG, Yee, F, Jazin, E, Yoo, H, Wahlested, C	J Biol Chem	1992
6589611	Cloning, characterization, and DNA sequence of a human cDNA encoding neuropeptide tyrosine Minth, CD, Bloom, SR, Polak, JM, Dixon, JE	Proc Natl Acad Sci U S A	1984
3202875	Isolation and primary structure of human peptide YY Tatemoto, K, Nakano, I, Makk, G, Angwin, P, Mann, M, Schilling, J, Go, VL	Biochem Biophys Res Commun	1988
7592910	Expression cloning and pharmacological characterization of a human hippocampal neuropeptide Y/peptide YY Y2 receptor subtype Gerald, C, Walker, MW, Vaysse, PJ, He, C, Branchek, TA, Weinshank, RL	J Biol Chem	1995