Neuropeptide Y receptors can bind neuropeptide Y-related peptides

Stable Identifier
R-HSA-388863
Type
Reaction [binding]
Species
Homo sapiens
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At least four neuropeptide Y receptor subtypes each with specific affinities to neuropeptide Y peptides, serve as regulators of mucosal function, gastrointestinal motility and secretion. Four receptors have been characterized to date; NPY1R (Larhammar D et al, 1992), NPY2R (Gerald C et al, 1995), NPY4R (Bard JA et al, 1995) and NPY5R (Parker EM and Xia L, 1999).

Neuropeptide Y peptides are also implicated as mediators in the pathogenesis of many gastrointestinal disorders, including malabsorption, short gut, inflammatory bowel diseases, and forms of pancreatitis. The three peptides are neuropeptide Y (NPY) (Minth CD et al, 1984), peptide YY (PYY) (Tatemoto K et al, 1988) and pancreatic peptide (PP) (Boel E et al, 1984).

Although each peptide can bind to any of the four receptors, they each have preferred receptors. NPY binds preferentially to NPY1R, PYY to NYP2R and PP to NYP4R.

Literature References
PubMed ID Title Journal Year
6373251 A cDNA encoding a small common precursor for human pancreatic polypeptide and pancreatic icosapeptide

Boel, E, Schwartz, TW, Norris, KE, Fiil, NP

EMBO J 1984
7592911 Cloning and functional expression of a human Y4 subtype receptor for pancreatic polypeptide, neuropeptide Y, and peptide YY

Bard, JA, Walker, MW, Branchek, TA, Weinshank, RL

J Biol Chem 1995
10461880 Extensive alternative splicing in the 5'-untranslated region of the rat and human neuropeptide Y Y5 receptor genes regulates receptor expression

Parker, EM, Xia, L

J Neurochem 1999
1317848 Cloning and functional expression of a human neuropeptide Y/peptide YY receptor of the Y1 type

Larhammar, D, Blomqvist, AG, Yee, F, Jazin, E, Yoo, H, Wahlested, C

J Biol Chem 1992
6589611 Cloning, characterization, and DNA sequence of a human cDNA encoding neuropeptide tyrosine

Minth, CD, Bloom, SR, Polak, JM, Dixon, JE

Proc Natl Acad Sci U S A 1984
3202875 Isolation and primary structure of human peptide YY

Tatemoto, K, Nakano, I, Makk, G, Angwin, P, Mann, M, Schilling, J, Go, VL

Biochem Biophys Res Commun 1988
7592910 Expression cloning and pharmacological characterization of a human hippocampal neuropeptide Y/peptide YY Y2 receptor subtype

Gerald, C, Walker, MW, Vaysse, PJ, He, C, Branchek, TA, Weinshank, RL

J Biol Chem 1995
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