Reactome | Prolactin-releasing hormone receptor binds PRH

Prolactin-releasing hormone receptor binds PRH

Stable Identifier

R-HSA-388855

Type

Reaction [binding]

Species

Homo sapiens

Compartment

extracellular region, plasma membrane

ReviewStatus

5/5

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Prolactin-releasing hormone receptor binds PRH

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The prolactin-releasing peptide receptor (PrRP; GRP10) (Marchese A et al, 1995) is expressed in the pituitary gland (Fujii R et al, 1999) and binds prolactin-releasing peptide (PrRP) (Hinuma S et al, 1998). PrRP is implicated in lactation, regulation of food intake and pain-signal processing. Human PrRP-20 failed to alter basal or forskolin-stimulated levels of intracellular cyclic AMP in HEK293-GPR10 cells, suggesting that GPR10 does not couple via either Gs or Gi (Langmead et al. 2000).

Literature References

PubMed ID	Title	Journal	Year
10498338	Tissue distribution of prolactin-releasing peptide (PrRP) and its receptor Fujii, R, Fukusumi, S, Hosoya, M, Kawamata, Y, Habata, Y, Hinuma, S, Sekiguchi, M, Kitada, C, Kurokawa, T, Nishimura, O, Onda, H, Sumino, Y, Fujino, M	Regul Pept	1999
8666380	Cloning and chromosomal mapping of three novel genes, GPR9, GPR10, and GPR14, encoding receptors related to interleukin 8, neuropeptide Y, and somatostatin receptors Marchese, A, Heiber, M, Nguyen, T, Heng, HH, Saldivia, VR, Cheng, R, Murphy, PM, Tsui, LC, Shi, X, Gregor, P	Genomics	1995
9607765	A prolactin-releasing peptide in the brain Hinuma, S, Habata, Y, Fujii, R, Kawamata, Y, Hosoya, M, Fukusumi, S, Kitada, C, Masuo, Y, Asano, T, Matsumoto, H, Sekiguchi, M, Kurokawa, T, Nishimura, O, Onda, H, Fujino, M	Nature	1998