Prolactin-releasing hormone receptor binds PRH

Stable Identifier
Reaction [binding]
Homo sapiens
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The prolactin-releasing peptide receptor (PrRP; GRP10) (Marchese A et al, 1995) is expressed in the pituitary gland (Fujii R et al, 1999) and binds prolactin-releasing peptide (PrRP) (Hinuma S et al, 1998). PrRP is implicated in lactation, regulation of food intake and pain-signal processing. Human PrRP-20 failed to alter basal or forskolin-stimulated levels of intracellular cyclic AMP in HEK293-GPR10 cells, suggesting that GPR10 does not couple via either Gs or Gi (Langmead et al. 2000).
Literature References
PubMed ID Title Journal Year
10498338 Tissue distribution of prolactin-releasing peptide (PrRP) and its receptor

Sekiguchi, M, Nishimura, O, Kitada, C, Habata, Y, Kawamata, Y, Onda, H, Hinuma, S, Fujino, M, Fujii, R, Hosoya, M, Kurokawa, T, Fukusumi, S, Sumino, Y

Regul Pept 1999
8666380 Cloning and chromosomal mapping of three novel genes, GPR9, GPR10, and GPR14, encoding receptors related to interleukin 8, neuropeptide Y, and somatostatin receptors

Murphy, PM, Nguyen, T, Gregor, P, Shi, X, Saldivia, VR, Marchese, A, Heng, HH, Cheng, R, Tsui, LC, Heiber, M

Genomics 1995
9607765 A prolactin-releasing peptide in the brain

Masuo, Y, Sekiguchi, M, Nishimura, O, Kitada, C, Asano, T, Kawamata, Y, Habata, Y, Onda, H, Matsumoto, H, Hinuma, S, Fujino, M, Fujii, R, Hosoya, M, Kurokawa, T, Fukusumi, S

Nature 1998
Orthologous Events
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