Prolactin-releasing hormone receptor binds PRH

Stable Identifier
R-HSA-388855
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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The prolactin-releasing peptide receptor (PrRP; GRP10) (Marchese A et al, 1995) is expressed in the pituitary gland (Fujii R et al, 1999) and binds prolactin-releasing peptide (PrRP) (Hinuma S et al, 1998). PrRP is implicated in lactation, regulation of food intake and pain-signal processing. Human PrRP-20 failed to alter basal or forskolin-stimulated levels of intracellular cyclic AMP in HEK293-GPR10 cells, suggesting that GPR10 does not couple via either Gs or Gi (Langmead et al. 2000).

Literature References
PubMed ID Title Journal Year
8666380 Cloning and chromosomal mapping of three novel genes, GPR9, GPR10, and GPR14, encoding receptors related to interleukin 8, neuropeptide Y, and somatostatin receptors

Marchese, A, Heiber, M, Nguyen, T, Heng, HH, Saldivia, VR, Cheng, R, Murphy, PM, Tsui, LC, Shi, X, Gregor, P

Genomics 1995
10498338 Tissue distribution of prolactin-releasing peptide (PrRP) and its receptor

Fujii, R, Fukusumi, S, Hosoya, M, Kawamata, Y, Habata, Y, Hinuma, S, Sekiguchi, M, Kitada, C, Kurokawa, T, Nishimura, O, Onda, H, Sumino, Y, Fujino, M

Regul Pept 1999
9607765 A prolactin-releasing peptide in the brain

Hinuma, S, Habata, Y, Fujii, R, Kawamata, Y, Hosoya, M, Fukusumi, S, Kitada, C, Masuo, Y, Asano, T, Matsumoto, H, Sekiguchi, M, Kurokawa, T, Nishimura, O, Onda, H, Fujino, M

Nature 1998
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