Reactome | MC5R [plasma membrane]

MC5R [plasma membrane]

Stable Identifier

R-HSA-388604

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

RecName: Full=Melanocortin receptor 5; AltName: Full=MC5-R; AltName: Full=MC-2;
GN Name=MC5R;
OS Homo sapiens, MC5R_HUMAN

Locations in the PathwayBrowser

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Developmental Biology (Homo sapiens)

- MITF-M-regulated melanocyte development (Homo sapiens)
  - Transcriptional and post-translational regulation of MITF-M expression and activity (Homo sapiens)
    - p-S133-CREB1 binds MITF promoter (Homo sapiens)
      - MSH:Melanocortin receptors [plasma membrane] (Homo sapiens)
        
        Melanocortin receptors [plasma membrane] (Homo sapiens)
        
        MC5R [plasma membrane] (Homo sapiens)

Signal Transduction (Homo sapiens)

- Signaling by GPCR (Homo sapiens)
  - GPCR downstream signalling (Homo sapiens)
    - G alpha (s) signalling events (Homo sapiens)
      - Liganded Gs-activating GPCR acts as a GEF for Gs (Homo sapiens)
        
        GPCR:ligand complexes that act on Gs:Heterotrimeric G-protein Gs (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
        
        MSH:Melanocortin receptors [plasma membrane] (Homo sapiens)
        
        Melanocortin receptors [plasma membrane] (Homo sapiens)
        
        MC5R [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gs:Heterotrimeric G-protein Gs (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
        
        MSH:Melanocortin receptors [plasma membrane] (Homo sapiens)
        
        Melanocortin receptors [plasma membrane] (Homo sapiens)
        
        MC5R [plasma membrane] (Homo sapiens)
      - Liganded Gs-activating GPCRs bind inactive heterotrimeric Gs (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
        
        MSH:Melanocortin receptors [plasma membrane] (Homo sapiens)
        
        Melanocortin receptors [plasma membrane] (Homo sapiens)
        
        MC5R [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gs:Heterotrimeric G-protein Gs (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
        
        MSH:Melanocortin receptors [plasma membrane] (Homo sapiens)
        
        Melanocortin receptors [plasma membrane] (Homo sapiens)
        
        MC5R [plasma membrane] (Homo sapiens)
      - The Ligand:GPCR:Gs complex dissociates (Homo sapiens)
        
        GPCR:ligand complexes that act on Gs:Heterotrimeric G-protein Gs (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
        
        MSH:Melanocortin receptors [plasma membrane] (Homo sapiens)
        
        Melanocortin receptors [plasma membrane] (Homo sapiens)
        
        MC5R [plasma membrane] (Homo sapiens)
        
        GPCRs that activate Gs [plasma membrane] (Homo sapiens)
        
        Melanocortin receptors [plasma membrane] (Homo sapiens)
        
        MC5R [plasma membrane] (Homo sapiens)
  - GPCR ligand binding (Homo sapiens)
    - Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
      - Peptide ligand-binding receptors (Homo sapiens)
        
        Melanocortin receptors bind melanocortins (Homo sapiens)
        
        MSH:Melanocortin receptors [plasma membrane] (Homo sapiens)
        
        Melanocortin receptors [plasma membrane] (Homo sapiens)
        
        MC5R [plasma membrane] (Homo sapiens)
        
        Melanocortin receptors [plasma membrane] (Homo sapiens)
        
        MC5R [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:P33032 MC5R

Gene Names

MC5R

Chain

chain:1-325

Reference Genes

BioGPS Gene:4161 MC5R

COSMIC (genes):MC5R MC5R

CTD Gene:4161 MC5R

dbSNP Gene:4161 MC5R

ENSEMBL:ENSG00000176136 MC5R

HGNC:6933 MC5R

KEGG:hsa:4161 MC5R

Monarch:4161 MC5R

NCBI Gene:4161 MC5R

OMIM:600042 MC5R

UCSC:P33032 MC5R

Reference Transcript

RefSeq:NM_005913.2 MC5R

Other Identifiers

1141_at

11740682_at

16851226

208565_PM_at

208565_at

3780335

3780336

3780337

3780338

3780339

3780340

3780341

3780342

3780343

3780345

4161

8020339

A_14_P128137

A_14_P200504

A_23_P50039

GE81574

GO:0004930

GO:0004977

GO:0005515

GO:0005737

GO:0005886

GO:0007186

GO:0007187

GO:0007189

GO:0016020

GO:0019222

GO:0042562

GO:0060089

HMNXSV003035032

ILMN_1779501

L27080_at

PH_hs_0013165

TC18000075.hg

g5174534_3p_at

Participates

as a member of

Melanocortin receptors [plasma membrane] (Homo sapiens)

Inferred To

Mc5r [plasma membrane] (Mus musculus)

Mc5r [plasma membrane] (Rattus norvegicus)

mc5rb [plasma membrane] (Danio rerio)

mc5r [plasma membrane] (Xenopus tropicalis)

MC5R [plasma membrane] (Bos taurus)

MC5R [plasma membrane] (Canis familiaris)

MC5R [plasma membrane] (Gallus gallus)

MC5R [plasma membrane] (Sus scrofa)

Cross References

RefSeq

NP_005904.1

Guide to Pharmacology - Targets

286

ENSEMBL

ENSP00000468086, ENST00000324750, ENSP00000318077, ENST00000589410, ENSG00000176136

OpenTargets

ENSG00000176136

ZINC - FDA approved

MC5R_HUMAN

ZINC - Substances

MC5R_HUMAN

ZINC target

P33032

PRO

P33032

GlyGen

P33032

PDB

8IOD, 8INR

ZINC - Investigational

MC5R_HUMAN

GeneCards

MC5R

HPA

ENSG00000176136-MC5R

Pharos - Targets

P33032

ZINC - Predictions - Purchasable

MC5R_HUMAN