Reactome | Cholecystokinin receptors bind cholecystokinin

Cholecystokinin receptors bind cholecystokinin

Stable Identifier

R-HSA-388529

Type

Reaction [binding]

Species

Homo sapiens

Compartment

extracellular region, plasma membrane

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Cholecystokinin receptors bind cholecystokinin

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Cholecystokinin (CCK, previously called pancreozymin) (Takahashi Y et al,1985) is a peptide hormone of the gastrointestinal system responsible for stimulating the digestion of fat and protein. CCK is synthesized by I-cells in the small intestine and secreted in the duodenum, causing the release of digestive enzymes and bile from the pancreas and gall-bladder respectively. It also acts as a hunger suppressant. CCK receptors bind CCK. In humans, there are two receptor types, A (Ulrich CD et al, 1993) and B (Pisegna JR et al, 1992). The A type are primarily distributed in the GI tract whereas the B type are primarily in the CNS. In the CNS, type B receptors modulate anxiety, analgesia, arousal, and neuroleptic activity.These receptors mediates the action of CCK by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.

Literature References

PubMed ID	Title	Journal	Year
1280419	Molecular cloning of the human brain and gastric cholecystokinin receptor: structure, functional expression and chromosomal localization Pisegna, JR, de Weerth, A, Huppi, K, Wank, SA	Biochem Biophys Res Commun	1992
8503909	Molecular cloning and functional expression of the human gallbladder cholecystokinin A receptor Ulrich, CD, Ferber, I, Holicky, E, Hadac, E, Buell, G, Miller, LJ	Biochem Biophys Res Commun	1993
3856870	Molecular cloning of the human cholecystokinin gene by use of a synthetic probe containing deoxyinosine Takahashi, Y, Kato, K, Hayashizaki, Y, Wakabayashi, T, Ohtsuka, E, Matsuki, S, Ikehara, M, Matsubara, K	Proc Natl Acad Sci U S A	1985