Reactome | Cholecystokinin receptors bind cholecystokinin

Cholecystokinin receptors bind cholecystokinin

Stable Identifier

R-HSA-388529

Type

Reaction [binding]

Species

Homo sapiens

Compartment

extracellular region, plasma membrane

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Cholecystokinin receptors bind cholecystokinin

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Cholecystokinin (CCK, previously called pancreozymin) (Takahashi Y et al,1985) is a peptide hormone of the gastrointestinal system responsible for stimulating the digestion of fat and protein. CCK is synthesized by I-cells in the small intestine and secreted in the duodenum, causing the release of digestive enzymes and bile from the pancreas and gall-bladder respectively. It also acts as a hunger suppressant. CCK receptors bind CCK. In humans, there are two receptor types, A (Ulrich CD et al, 1993) and B (Pisegna JR et al, 1992). The A type are primarily distributed in the GI tract whereas the B type are primarily in the CNS. In the CNS, type B receptors modulate anxiety, analgesia, arousal, and neuroleptic activity.These receptors mediates the action of CCK by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.

Literature References

PubMed ID	Title	Journal	Year
8503909	Molecular cloning and functional expression of the human gallbladder cholecystokinin A receptor Ulrich, CD, Ferber, I, Holicky, E, Hadac, E, Buell, G, Miller, LJ	Biochem Biophys Res Commun	1993
1280419	Molecular cloning of the human brain and gastric cholecystokinin receptor: structure, functional expression and chromosomal localization Pisegna, JR, de Weerth, A, Huppi, K, Wank, SA	Biochem Biophys Res Commun	1992
3856870	Molecular cloning of the human cholecystokinin gene by use of a synthetic probe containing deoxyinosine Takahashi, Y, Kato, K, Hayashizaki, Y, Wakabayashi, T, Ohtsuka, E, Matsuki, S, Ikehara, M, Matsubara, K	Proc Natl Acad Sci U S A	1985