Cholecystokinin (CCK, previously called pancreozymin) (Takahashi Y et al,1985) is a peptide hormone of the gastrointestinal system responsible for stimulating the digestion of fat and protein. CCK is synthesized by I-cells in the small intestine and secreted in the duodenum, causing the release of digestive enzymes and bile from the pancreas and gall-bladder respectively. It also acts as a hunger suppressant. CCK receptors bind CCK. In humans, there are two receptor types, A (Ulrich CD et al, 1993) and B (Pisegna JR et al, 1992). The A type are primarily distributed in the GI tract whereas the B type are primarily in the CNS. In the CNS, type B receptors modulate anxiety, analgesia, arousal, and neuroleptic activity.These receptors mediates the action of CCK by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.
Buell, G, Ferber, I, Miller, LJ, Ulrich, CD, Holicky, E, Hadac, E
de Weerth, A, Wank, SA, Pisegna, JR, Huppi, K
Kato, K, Matsuki, S, Matsubara, K, Ohtsuka, E, Ikehara, M, Wakabayashi, T, Takahashi, Y, Hayashizaki, Y
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