Cholecystokinin (CCK, previously called pancreozymin) (Takahashi Y et al,1985) is a peptide hormone of the gastrointestinal system responsible for stimulating the digestion of fat and protein. CCK is synthesized by I-cells in the small intestine and secreted in the duodenum, causing the release of digestive enzymes and bile from the pancreas and gall-bladder respectively. It also acts as a hunger suppressant. CCK receptors bind CCK. In humans, there are two receptor types, A (Ulrich CD et al, 1993) and B (Pisegna JR et al, 1992). The A type are primarily distributed in the GI tract whereas the B type are primarily in the CNS. In the CNS, type B receptors modulate anxiety, analgesia, arousal, and neuroleptic activity.These receptors mediates the action of CCK by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.
Pisegna, JR, de Weerth, A, Huppi, K, Wank, SA
Ulrich, CD, Ferber, I, Holicky, E, Hadac, E, Buell, G, Miller, LJ
Takahashi, Y, Kato, K, Hayashizaki, Y, Wakabayashi, T, Ohtsuka, E, Matsuki, S, Ikehara, M, Matsubara, K
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