DCN (decorin) degradation by MMP14

Stable Identifier
R-HSA-3828025
Type
Reaction [transition]
Species
Homo sapiens
Compartment
plasma membrane, extracellular region
ReviewStatus
5/5
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DCN (decorin) degradation by MMP14
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MMP14 (MT1-MMP) is able to degrade decorin in keratocytes during bFGF-induced corneal neovascularization.
Literature References
PubMed ID Title Journal Year
19571574 MT1-MMP-mediated cleavage of decorin in corneal angiogenesis

Chang, JH, Mimura, T, Zhou, Z, Onguchi, T, Kojima, T, Kim, TI, Han, KY, Azar, DT

J. Vasc. Res. 2009
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Output
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Catalyst Activity

metalloendopeptidase activity of MMP14,TMPRSS6 [plasma membrane]

Physical Entity
MMP14,TMPRSS6 [plasma membrane] (Homo sapiens)
Activity
metalloendopeptidase activity (GO:0004222)
Orthologous Events
DCN (decorin) degradation by MMP14 (Bos taurus)
DCN (decorin) degradation by MMP14 (Canis familiaris)
DCN (decorin) degradation by MMP14 (Danio rerio)
DCN (decorin) degradation by MMP14 (Drosophila melanogaster)
DCN (decorin) degradation by MMP14 (Gallus gallus)
DCN (decorin) degradation by MMP14 (Mus musculus)
DCN (decorin) degradation by MMP14 (Rattus norvegicus)
DCN (decorin) degradation by MMP14 (Sus scrofa)
Authored
Jupe, S  (2012-08-08)
Reviewed
Ricard-Blum, S  (2013-08-13)
Created
Jupe, S  (2013-07-09)
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