Extracellular processing of novel PDGFs

Stable Identifier
R-HSA-382061
Type
Reaction
Species
Homo sapiens
Compartment
extracellular region
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Extracellular processing of novel PDGFs
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During the extracellular proteolytic activation of PDGF-C and PDGF-D chains, the CUB domains is removed and plasmin protease has been shown to proteolytically cleave within the hinge regions, and thus releasing the corresponding growth factor domains. In addition the protease tissue-type plasminogen activator (tPA) is also involved in the activation of PDGF-CC but not able to cleave and activate PDGF-DD.

Literature References
PubMed ID Title Journal Year
15207811 The PDGF family: four gene products form five dimeric isoforms

Li, H, Eriksson, U, Fredriksson, L

Cytokine Growth Factor Rev 2004
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Output
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as an event of
Catalyst Activity

serine-type endopeptidase activity of serine-type endopeptidases involved in novel PDGF processing [extracellular region]

Physical Entity
serine-type endopeptidases involved in novel PDGF processing [extracellular region] (Homo sapiens)
Activity
serine-type endopeptidase activity (GO:0004252)
Orthologous Events
Extracellular processing of novel PDGFs (Bos taurus)
Extracellular processing of novel PDGFs (Canis familiaris)
Extracellular processing of novel PDGFs (Danio rerio)
Extracellular processing of novel PDGFs (Gallus gallus)
Extracellular processing of novel PDGFs (Mus musculus)
Extracellular processing of novel PDGFs (Rattus norvegicus)
Extracellular processing of novel PDGFs (Sus scrofa)
Authored
Jassal, B  (2008-11-24)
Garapati, P V  (2008-11-24)
Reviewed
Heldin, CH  (2008-11-23)
Created
Garapati, P V  (2008-11-21)
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