ATF6 (ATF6-alpha) translocates from the cytosol to the nucleus

Stable Identifier
R-HSA-381026
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
cytosol, nucleoplasm
ReviewStatus
5/5
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ATF6 (ATF6-alpha) translocates from the cytosol to the nucleus
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The cytosolic N-terminal cleavage product of ATF6-alpha transits to the nucleus.
Literature References
PubMed ID Title Journal Year
10564271 Mammalian transcription factor ATF6 is synthesized as a transmembrane protein and activated by proteolysis in response to endoplasmic reticulum stress

Mori, K, Yoshida, H, Yanagi, H, Haze, K, Yura, T

Mol Biol Cell 1999
10856300 Activation of ATF6 and an ATF6 DNA binding site by the endoplasmic reticulum stress response

Kaufman, RJ, Shen, J, Wang, Y, Arenzana, N, Prywes, R, Tirasophon, W

J Biol Chem 2000
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Orthologous Events
ATF6 (ATF6-alpha) translocates from the cytosol to the nucleus (Bos taurus)
ATF6 (ATF6-alpha) translocates from the cytosol to the nucleus (Caenorhabditis elegans)
ATF6 (ATF6-alpha) translocates from the cytosol to the nucleus (Canis familiaris)
ATF6 (ATF6-alpha) translocates from the cytosol to the nucleus (Dictyostelium discoideum)
ATF6 (ATF6-alpha) translocates from the cytosol to the nucleus (Drosophila melanogaster)
ATF6 (ATF6-alpha) translocates from the cytosol to the nucleus (Gallus gallus)
ATF6 (ATF6-alpha) translocates from the cytosol to the nucleus (Mus musculus)
ATF6 (ATF6-alpha) translocates from the cytosol to the nucleus (Rattus norvegicus)
ATF6 (ATF6-alpha) translocates from the cytosol to the nucleus (Sus scrofa)
ATF6 (ATF6-alpha) translocates from the cytosol to the nucleus (Xenopus tropicalis)
CREB3 translocates from the cytosol to the nucleus (Homo sapiens)
Authored
May, B  (2009-06-02)
Reviewed
Gillespie, ME  (2008-12-02)
D'Eustachio, P  (2008-12-02)
Matthews, L  (2008-12-02)
Urano, F  (2010-04-30)
Created
May, B  (2008-11-19)
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