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AP-1 transcription factor binds IGFBP7 promoter
Stable Identifier
R-HSA-3797196
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Cellular Senescence (Homo sapiens)
Senescence-Associated Secretory Phenotype (SASP) (Homo sapiens)
AP-1 transcription factor binds IGFBP7 promoter (Homo sapiens)
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
FOS:JUN (AP-1) transcription factor, formed in response to oncogenic RAF-MAPK signaling which also triggers oxidative stress, binds the promoter of IGFBP7 gene (Wajapeyee et al. 2008).
Literature References
PubMed ID
Title
Journal
Year
18267069
Oncogenic BRAF induces senescence and apoptosis through pathways mediated by the secreted protein IGFBP7
Zhu, X
,
Wajapeyee, N
,
Serra, RW
,
Green, MR
,
Mahalingam, M
Cell
2008
Participants
Input
IGFBP7 gene [nucleoplasm]
(Homo sapiens)
p-2S-cJUN:p-2S,2T-cFOS [nucleoplasm]
(Homo sapiens)
Output
p-2S-JUN:p-2S,2T-FOS:IGFBP7 Gene [nucleoplasm]
(Homo sapiens)
Participates
as an event of
Senescence-Associated Secretory Phenotype (SASP) (Homo sapiens)
Authored
Orlic-Milacic, M (2013-07-15)
Reviewed
Samarajiwa, S (2013-09-03)
Created
Orlic-Milacic, M (2013-07-05)
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