Reactome | SLC7A6 [plasma membrane]

SLC7A6 [plasma membrane]

Stable Identifier

R-HSA-379425

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Y+L amino acid transporter 2

Locations in the PathwayBrowser

Expand all

Hemostasis (Homo sapiens)

- Cell surface interactions at the vascular wall (Homo sapiens)
  - Basigin interactions (Homo sapiens)
    - Basigin binds CD98 complex (Homo sapiens)
      - Basigin:CD98hc complex [plasma membrane] (Homo sapiens)
        
        CD98hc complex [plasma membrane] (Homo sapiens)
        
        SLC7A6:SLC3A2 heterodimer [plasma membrane] (Homo sapiens)
        
        SLC7A6 [plasma membrane] (Homo sapiens)
      - CD98hc complex [plasma membrane] (Homo sapiens)
        
        SLC7A6:SLC3A2 heterodimer [plasma membrane] (Homo sapiens)
        
        SLC7A6 [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q92536 SLC7A6

Gene Names

SLC7A6, KIAA0245

Chain

chain:1-515

Reference Genes

BioGPS Gene:9057 SLC7A6

COSMIC (genes):SLC7A6 SLC7A6

CTD Gene:9057 SLC7A6

dbSNP Gene:9057 SLC7A6

ENSEMBL:ENSG00000103064 SLC7A6

ENSEMBL_homo_sapiens_GENE:ENSG00000103064.15 SLC7A6

HGNC:11064 SLC7A6

KEGG Gene (Homo sapiens):9057 SLC7A6

Monarch:9057 SLC7A6

NCBI Gene:9057 SLC7A6

OMIM:605641 SLC7A6

UCSC:Q92536 SLC7A6

Reference Transcript

Other Identifiers

11725508_a_at

11725509_a_at

11725510_a_at

16820398

203578_PM_s_at

203578_s_at

203579_PM_s_at

203579_s_at

203580_PM_s_at

203580_s_at

3666147

3666150

3666157

3666170

3666172

3666173

3666176

3666177

3666178

3666180

3666181

3666182

3666183

3666184

3666185

3666186

3666187

3666188

39533_at

7996772

9057

A_14_P115369

A_14_P133612

A_14_P200444

A_23_P88831

A_24_P159312

D87432_at

GE62752

GO:0003333

GO:0005215

GO:0005515

GO:0005886

GO:0006809

GO:0006865

GO:0015171

GO:0015174

GO:0015179

GO:0015297

GO:0015804

GO:0015820

GO:0015822

GO:0016020

GO:0022857

GO:0031460

GO:0034618

GO:0055085

GO:0061459

GO:0106439

GO:1903401

GO:1903826

HMNXSV003003097

HMNXSV003034058

Hs.10315.0.S1_3p_a_at

Hs.10315.0.S2_3p_a_at

ILMN_1812559

ILMN_2324561

PH_hs_0036211

TC16000554.hg

g4507052_3p_a_at

Participates

as a component of

SLC7A6:SLC3A2 heterodimer [plasma membrane] (Homo sapiens)

Inferred To

Dmel\CG1607 [plasma membrane] (Drosophila melanogaster)

Homologues of SLC7A6 [plasma membrane] (Drosophila melanogaster)

SLC7A6 [plasma membrane] (Bos taurus)

SLC7A6 [plasma membrane] (Canis familiaris)

gb [plasma membrane] (Drosophila melanogaster)

Slc7a6 [plasma membrane] (Mus musculus)

Slc7a6 [plasma membrane] (Rattus norvegicus)

slc7a6 [plasma membrane] (Danio rerio)

slc7a6 [plasma membrane] (Xenopus tropicalis)

mnd [plasma membrane] (Drosophila melanogaster)

JhI-21 [plasma membrane] (Drosophila melanogaster)

Cross References

RefSeq

XP_011521735.1, NP_001070253.1, NP_003974.3, XP_011521736.1, XP_011521740.1

Guide to Pharmacology - Targets

899

OpenTargets

ENSG00000103064

HPA

ENSG00000103064-SLC7A6

GeneCards

Q92536

Ensembl

ENST00000566454, ENSG00000103064, ENSP00000455064, ENSP00000219343, ENST00000219343

PRO

Q92536

Pharos - Targets

Q92536

HMDB Protein

HMDBP09098

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9UPQ8 DOLK	6	DOLK [endoplasmic reticulum membrane] (R-HSA-449274) DOLK M1I [endoplasmic reticulum membrane] (R-HSA-4755593) DOLK H408D [endoplasmic reticulum membrane] (R-HSA-4755548) DOLK C99S [endoplasmic reticulum membrane] (R-HSA-4755602) DOLK W304C [endoplasmic reticulum membrane] (R-HSA-4755557) DOLK Y441S [endoplasmic reticulum membrane] (R-HSA-4755590)	0.556	3