Reactome | SLC7A6 [plasma membrane]

SLC7A6 [plasma membrane]

Stable Identifier

R-HSA-379425

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Y+L amino acid transporter 2

Locations in the PathwayBrowser

Expand all

Hemostasis (Homo sapiens)

- Cell surface interactions at the vascular wall (Homo sapiens)
  - Basigin interactions (Homo sapiens)
    - Basigin binds CD98 complex (Homo sapiens)
      - Basigin:CD98hc complex [plasma membrane] (Homo sapiens)
        
        CD98hc complex [plasma membrane] (Homo sapiens)
        
        SLC7A6:SLC3A2 heterodimer [plasma membrane] (Homo sapiens)
        
        SLC7A6 [plasma membrane] (Homo sapiens)
      - CD98hc complex [plasma membrane] (Homo sapiens)
        
        SLC7A6:SLC3A2 heterodimer [plasma membrane] (Homo sapiens)
        
        SLC7A6 [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q92536 SLC7A6

Gene Names

SLC7A6, KIAA0245

Chain

chain:1-515

Reference Genes

BioGPS Gene:9057 SLC7A6

COSMIC (genes):SLC7A6 SLC7A6

CTD Gene:9057 SLC7A6

dbSNP Gene:9057 SLC7A6

ENSEMBL:ENSG00000103064 SLC7A6

HGNC:11064 SLC7A6

KEGG:hsa:9057 SLC7A6

Monarch:9057 SLC7A6

NCBI Gene:9057 SLC7A6

OMIM:605641 SLC7A6

UCSC:Q92536 SLC7A6

Reference Transcript

Other Identifiers

11725508_a_at

11725509_a_at

11725510_a_at

16820398

203578_PM_s_at

203578_s_at

203579_PM_s_at

203579_s_at

203580_PM_s_at

203580_s_at

3666145

3666147

3666148

3666150

3666152

3666157

3666158

3666159

3666168

3666169

3666170

3666171

3666172

3666173

3666174

3666175

3666176

3666177

3666178

3666179

3666180

3666181

3666182

3666183

3666184

3666185

3666186

3666187

3666188

39533_at

7996772

9057

A_14_P108560

A_14_P115369

A_14_P133612

A_14_P200444

A_23_P88831

A_24_P159312

D87432_at

GE62752

GO:0003333

GO:0005215

GO:0005515

GO:0005886

GO:0006809

GO:0006865

GO:0015171

GO:0015174

GO:0015179

GO:0015297

GO:0015804

GO:0015820

GO:0015822

GO:0016020

GO:0022857

GO:0031460

GO:0034618

GO:0055085

GO:0061459

GO:0106439

GO:1902475

GO:1903401

GO:1903826

HMNXSV003003097

HMNXSV003034058

Hs.10315.0.S1_3p_a_at

Hs.10315.0.S2_3p_a_at

ILMN_1812559

ILMN_2324561

PH_hs_0036211

TC16000554.hg

g4507052_3p_a_at

Participates

as a component of

SLC7A6:SLC3A2 heterodimer [plasma membrane] (Homo sapiens)

Inferred To

Dmel\CG1607 [plasma membrane] (Drosophila melanogaster)

Homologues of SLC7A6 [plasma membrane] (Drosophila melanogaster)

SLC7A6 [plasma membrane] (Bos taurus)

SLC7A6 [plasma membrane] (Canis familiaris)

gb [plasma membrane] (Drosophila melanogaster)

Slc7a6 [plasma membrane] (Mus musculus)

Slc7a6 [plasma membrane] (Rattus norvegicus)

slc7a6 [plasma membrane] (Danio rerio)

slc7a6 [plasma membrane] (Xenopus tropicalis)

mnd [plasma membrane] (Drosophila melanogaster)

JhI-21 [plasma membrane] (Drosophila melanogaster)

Cross References

Guide to Pharmacology - Targets

899

ENSEMBL

ENSG00000103064, ENSP00000219343, ENST00000219343, ENST00000566454, ENSP00000455064

OpenTargets

ENSG00000103064

GeneCards

SLC7A6

HPA

ENSG00000103064-SLC7A6

PRO

Q92536

Pharos - Targets

Q92536

HMDB Protein

HMDBP09098

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9UPQ8 DOLK	6	DOLK [endoplasmic reticulum membrane] (R-HSA-449274) DOLK M1I [endoplasmic reticulum membrane] (R-HSA-4755593) DOLK H408D [endoplasmic reticulum membrane] (R-HSA-4755548) DOLK C99S [endoplasmic reticulum membrane] (R-HSA-4755602) DOLK W304C [endoplasmic reticulum membrane] (R-HSA-4755557) DOLK Y441S [endoplasmic reticulum membrane] (R-HSA-4755590)	0.556	3