Cdh1:APC/C ubiquitinates EHMT1 and EHMT2

Stable Identifier
R-HSA-3788724
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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Cdh1:APC/C ubiquitinates EHMT1 and EHMT2
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Cdh1:APC/C complex, stabilized by the DNA damage-induced ATM-TP53-CDKN1A axis, ubiquitinates EHMT1 (GLP) and EHMT2 (G9a) histone methyltransferases, targeting them for degradation (Takahashi et al. 2012).
Literature References
PubMed ID Title Journal Year
22178396 DNA damage signaling triggers degradation of histone methyltransferases through APC/C(Cdh1) in senescent cells

Peters, G, Yoshimoto, S, Shinkai, Y, Imai, Y, Tachibana, M, Takahashi, A, Saya, H, Takeuchi, T, Hori, S, Hara, E, Kuninaka, S, Yamakoshi, K, Ohtani, N, Anderton, E

Mol. Cell 2012
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as an event of
Catalyst Activity

ubiquitin-protein transferase activity of EHMT1:EHMT2:Cdh1:p-APC/C [nucleoplasm]

Physical Entity
EHMT1:EHMT2:Cdh1:p-APC/C [nucleoplasm] (Homo sapiens)
Activity
ubiquitin-protein transferase activity (GO:0004842)
Orthologous Events
Cdh1:APC/C ubiquitinates EHMT1 and EHMT2 (Bos taurus)
Cdh1:APC/C ubiquitinates EHMT1 and EHMT2 (Canis familiaris)
Cdh1:APC/C ubiquitinates EHMT1 and EHMT2 (Dictyostelium discoideum)
Cdh1:APC/C ubiquitinates EHMT1 and EHMT2 (Drosophila melanogaster)
Cdh1:APC/C ubiquitinates EHMT1 and EHMT2 (Gallus gallus)
Cdh1:APC/C ubiquitinates EHMT1 and EHMT2 (Mus musculus)
Cdh1:APC/C ubiquitinates EHMT1 and EHMT2 (Rattus norvegicus)
Cdh1:APC/C ubiquitinates EHMT1 and EHMT2 (Sus scrofa)
Cdh1:APC/C ubiquitinates EHMT1 and EHMT2 (Xenopus tropicalis)
Authored
Orlic-Milacic, M  (2013-07-15)
Reviewed
Samarajiwa, S  (2013-09-03)
Created
Orlic-Milacic, M  (2013-07-04)
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