Reactome | Cdh1:APC/C ubiquitinates EHMT1 and EHMT2

Cdh1:APC/C ubiquitinates EHMT1 and EHMT2

Stable Identifier

R-HSA-3788724

Type

Reaction [transition]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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Cdh1:APC/C ubiquitinates EHMT1 and EHMT2

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Cdh1:APC/C complex, stabilized by the DNA damage-induced ATM-TP53-CDKN1A axis, ubiquitinates EHMT1 (GLP) and EHMT2 (G9a) histone methyltransferases, targeting them for degradation (Takahashi et al. 2012).

Literature References

PubMed ID	Title	Journal	Year
22178396	DNA damage signaling triggers degradation of histone methyltransferases through APC/C(Cdh1) in senescent cells Peters, G, Yoshimoto, S, Shinkai, Y, Imai, Y, Tachibana, M, Takahashi, A, Saya, H, Takeuchi, T, Hori, S, Hara, E, Kuninaka, S, Yamakoshi, K, Ohtani, N, Anderton, E	Mol. Cell	2012