Clustering of Integrin alphaIIb beta3 complexes

Stable Identifier
R-HSA-377641
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Clustering of Integrin alphaIIb beta3 complexes
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

The fibrinogen-bound integrin alphaIIb beta3 clusters platelets together to form a platelet plug and generates intracellular signals (outside-in) causing further platelet activation and platelet plug retraction.
Intracellular integrin alphaIIb beta3 clustering brings SRCs bound to integrin beta3 chains into proximity. SRC associates constitutively with integrin alphaIIb beta3. In unstimulated cells this SRC is inactive, auto-inhibited by an internal interaction between phosphorylated Y530 and the SH2 domain. CSK is selective for the Y530 residue and prevents access to SRC of PTP1B, a protein tyrosine phosphatase that is capable of de-phosphorylating Y530.

Literature References
PubMed ID Title Journal Year
16005629 Integrins and Src: dynamic duo of adhesion signaling

Shattil, SJ

Trends Cell Biol 2005
15157149 Structural basis for integrin alphaIIbbeta3 clustering

Li, R, Bennett, JS, DeGrado, WF

Biochem Soc Trans 2004
Participants
Input
Output
Participant Of
hasEvent
Orthologous Events
Clustering of Integrin alphaIIb beta3 complexes (Danio rerio)
Clustering of Integrin alphaIIb beta3 complexes (Mus musculus)
Clustering of Integrin alphaIIb beta3 complexes (Rattus norvegicus)
Clustering of Integrin alphaIIb beta3 complexes (Xenopus tropicalis)
Authored
Garapati, P V  (2008-06-16)
Reviewed
Shattil, SJ  (2008-09-16)
Created
Garapati, P V  (2008-09-15)
Cite Us!