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About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
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Content Service
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Pathway Diagrams
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Curator Guide
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FAQ
Linking to Us
Citing us
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Analyse gene list
Analyse gene expression
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p-Y530-SRC:CSK [cytosol]
Stable Identifier
R-HSA-377606
Type
Complex
Species
Homo sapiens
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
Oncogenic MAPK signaling (Homo sapiens)
Paradoxical activation of RAF signaling by kinase inactive BRAF (Homo sapiens)
Activated MAP2Ks phosphorylate MAPKs downstream of inactive BRAF mutants (Homo sapiens)
RAS:GTP: inactive p-RAF:p-2S MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Homo sapiens)
p-Y530-SRC:CSK [cytosol] (Homo sapiens)
RAS:GTP:inactive p-RAF:p-2S MAP2Ks:p-T,Y MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Homo sapiens)
p-Y530-SRC:CSK [cytosol] (Homo sapiens)
Dissociation of paradoxically activated RAS:BRAF complexes (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Homo sapiens)
p-Y530-SRC:CSK [cytosol] (Homo sapiens)
RAS:GTP:inactive p-RAF:p-2S MAP2Ks:p-T,Y MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Homo sapiens)
p-Y530-SRC:CSK [cytosol] (Homo sapiens)
RAS:GTP:inactive p-RAF complexes phosphorylate MAP2Ks (Homo sapiens)
RAS:GTP: inactive p-RAF:p-2S MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Homo sapiens)
p-Y530-SRC:CSK [cytosol] (Homo sapiens)
RAS:GTP:inactive p-RAF:MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Homo sapiens)
p-Y530-SRC:CSK [cytosol] (Homo sapiens)
RAS:GTP:p-RAF complexes paradoxically bind MAP2Ks and MAPKs (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Homo sapiens)
p-Y530-SRC:CSK [cytosol] (Homo sapiens)
RAS:GTP:inactive p-RAF:MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Homo sapiens)
p-Y530-SRC:CSK [cytosol] (Homo sapiens)
Signaling by BRAF and RAF1 fusions (Homo sapiens)
Dissociation of BRAF/RAF fusion complex (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Homo sapiens)
p-Y530-SRC:CSK [cytosol] (Homo sapiens)
p-BRAF/RAF fusion dimers:p-2S MAP2Ks:p-T,Y MAPKs:scaffold proteins [cytosol] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Homo sapiens)
p-Y530-SRC:CSK [cytosol] (Homo sapiens)
MAPKs are phosphorylated downstream of BRAF and RAF fusion dimers (Homo sapiens)
p-BRAF/RAF fusion dimers:p-2S MAP2Ks:MAPKs:scaffold proteins [cytosol] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Homo sapiens)
p-Y530-SRC:CSK [cytosol] (Homo sapiens)
p-BRAF/RAF fusion dimers:p-2S MAP2Ks:p-T,Y MAPKs:scaffold proteins [cytosol] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Homo sapiens)
p-Y530-SRC:CSK [cytosol] (Homo sapiens)
p-BRAF and RAF fusion dimers bind MAP2Ks and MAPKs (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Homo sapiens)
p-Y530-SRC:CSK [cytosol] (Homo sapiens)
p-BRAF/RAF fusion dimers:MAP2Ks:MAPKs:scaffold proteins [cytosol] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Homo sapiens)
p-Y530-SRC:CSK [cytosol] (Homo sapiens)
p-BRAF and RAF fusion dimers phosphorylate MAP2Ks (Homo sapiens)
p-BRAF/RAF fusion dimers:MAP2Ks:MAPKs:scaffold proteins [cytosol] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Homo sapiens)
p-Y530-SRC:CSK [cytosol] (Homo sapiens)
p-BRAF/RAF fusion dimers:p-2S MAP2Ks:MAPKs:scaffold proteins [cytosol] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Homo sapiens)
p-Y530-SRC:CSK [cytosol] (Homo sapiens)
Signaling by RAF1 mutants (Homo sapiens)
Dissociation of RAS:RAF1 mutant complex (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Homo sapiens)
p-Y530-SRC:CSK [cytosol] (Homo sapiens)
activated RAF1 mutant:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Homo sapiens)
p-Y530-SRC:CSK [cytosol] (Homo sapiens)
MAP2Ks and MAPKs bind to the activated mutant RAF1 complex (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Homo sapiens)
p-Y530-SRC:CSK [cytosol] (Homo sapiens)
activated RAF1 mutant:scaffold:MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Homo sapiens)
p-Y530-SRC:CSK [cytosol] (Homo sapiens)
MAP2Ks phosphorylate MAPKs downstream of RAF1 mutants (Homo sapiens)
activated RAF1 mutant:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Homo sapiens)
p-Y530-SRC:CSK [cytosol] (Homo sapiens)
activated RAF1 mutant:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Homo sapiens)
p-Y530-SRC:CSK [cytosol] (Homo sapiens)
RAF1 mutant complexes phosphorylate MAP2K dimer (Homo sapiens)
activated RAF1 mutant:scaffold:MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Homo sapiens)
p-Y530-SRC:CSK [cytosol] (Homo sapiens)
activated RAF1 mutant:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Homo sapiens)
p-Y530-SRC:CSK [cytosol] (Homo sapiens)
Signaling by RAS mutants (Homo sapiens)
Signaling downstream of RAS mutants (Homo sapiens)
Activated MAP2Ks phosphorylate MAPKs downstream of oncogenic RAS (Homo sapiens)
mutant RAS:GTP:p-RAF:p-2S MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Homo sapiens)
p-Y530-SRC:CSK [cytosol] (Homo sapiens)
mutant RAS:GTP:p-RAF:p-2S MAP2Ks:p-T,Y MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Homo sapiens)
p-Y530-SRC:CSK [cytosol] (Homo sapiens)
Dissociation of oncogenic RAS:RAF complex (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Homo sapiens)
p-Y530-SRC:CSK [cytosol] (Homo sapiens)
mutant RAS:GTP:p-RAF:p-2S MAP2Ks:p-T,Y MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Homo sapiens)
p-Y530-SRC:CSK [cytosol] (Homo sapiens)
Mutant RAS:p-RAF complexes bind MAP2Ks and MAPKs (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Homo sapiens)
p-Y530-SRC:CSK [cytosol] (Homo sapiens)
mutant RAS:GTP:p-RAF:MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Homo sapiens)
p-Y530-SRC:CSK [cytosol] (Homo sapiens)
Mutant RAS:p-RAF complexes phosphorylate MAP2Ks (Homo sapiens)
mutant RAS:GTP:p-RAF:MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Homo sapiens)
p-Y530-SRC:CSK [cytosol] (Homo sapiens)
mutant RAS:GTP:p-RAF:p-2S MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Homo sapiens)
p-Y530-SRC:CSK [cytosol] (Homo sapiens)
Signaling by high-kinase activity BRAF mutants (Homo sapiens)
Activated MAP2Ks phosphorylate MAPKs downstream of high kinase activity BRAF mutants (Homo sapiens)
high kinase activity BRAF mutants:scaffold:p-2S MAP2K:MAPK complex [cytosol] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Homo sapiens)
p-Y530-SRC:CSK [cytosol] (Homo sapiens)
high kinase activity BRAF mutants:scaffold:p-2S MAP2K:p-T,Y MAPK complex [cytosol] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Homo sapiens)
p-Y530-SRC:CSK [cytosol] (Homo sapiens)
Dissociation of high activity BRAF complexes (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Homo sapiens)
p-Y530-SRC:CSK [cytosol] (Homo sapiens)
high kinase activity BRAF mutants:scaffold:p-2S MAP2K:p-T,Y MAPK complex [cytosol] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Homo sapiens)
p-Y530-SRC:CSK [cytosol] (Homo sapiens)
High kinase activity BRAF complexes phosphorylate MAP2Ks (Homo sapiens)
high kinase activity BRAF mutants:scaffold:MAP2K:MAPK complex [cytosol] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Homo sapiens)
p-Y530-SRC:CSK [cytosol] (Homo sapiens)
high kinase activity BRAF mutants:scaffold:p-2S MAP2K:MAPK complex [cytosol] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Homo sapiens)
p-Y530-SRC:CSK [cytosol] (Homo sapiens)
High kinase activity BRAF mutants bind MAP2Ks and MAPKs (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Homo sapiens)
p-Y530-SRC:CSK [cytosol] (Homo sapiens)
high kinase activity BRAF mutants:scaffold:MAP2K:MAPK complex [cytosol] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Homo sapiens)
p-Y530-SRC:CSK [cytosol] (Homo sapiens)
Signaling by moderate kinase activity BRAF mutants (Homo sapiens)
Activated MAP2Ks phosphorylate MAPKs downstream of moderate kinase activity BRAF mutants (Homo sapiens)
RAS:GTP:moderate kinase activity p-RAF:p-2S MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Homo sapiens)
p-Y530-SRC:CSK [cytosol] (Homo sapiens)
RAS:GTP:moderate kinase activity p-RAF:p-2S MAP2Ks:p-T,Y MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Homo sapiens)
p-Y530-SRC:CSK [cytosol] (Homo sapiens)
Dissociation of moderate activity BRAF complexes (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Homo sapiens)
p-Y530-SRC:CSK [cytosol] (Homo sapiens)
RAS:GTP:moderate kinase activity p-RAF:p-2S MAP2Ks:p-T,Y MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Homo sapiens)
p-Y530-SRC:CSK [cytosol] (Homo sapiens)
RAS:GTP:moderate kinase activity p-RAF complexes bind MAP2Ks and MAPKs (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Homo sapiens)
p-Y530-SRC:CSK [cytosol] (Homo sapiens)
RAS:GTP:moderate kinase activity p-RAF:MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Homo sapiens)
p-Y530-SRC:CSK [cytosol] (Homo sapiens)
RAS:GTP:moderate kinase activity p-RAF complexes phosphorylate MAP2Ks (Homo sapiens)
RAS:GTP:moderate kinase activity p-RAF:MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Homo sapiens)
p-Y530-SRC:CSK [cytosol] (Homo sapiens)
RAS:GTP:moderate kinase activity p-RAF:p-2S MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Homo sapiens)
p-Y530-SRC:CSK [cytosol] (Homo sapiens)
Hemostasis (Homo sapiens)
Platelet activation, signaling and aggregation (Homo sapiens)
Platelet Aggregation (Plug Formation) (Homo sapiens)
Integrin signaling (Homo sapiens)
Activated integrin alphaIIb beta3 binds SHC1 (Homo sapiens)
Integrin alphaIIb beta 3:p(Y530)-SRC:CSK:Talin:RIAM complex:SHC [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Homo sapiens)
p-Y530-SRC:CSK [cytosol] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Homo sapiens)
p-Y530-SRC:CSK [cytosol] (Homo sapiens)
Clustering of Integrin alphaIIb beta3 complexes (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Homo sapiens)
p-Y530-SRC:CSK [cytosol] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Homo sapiens)
p-Y530-SRC:CSK [cytosol] (Homo sapiens)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Homo sapiens)
p-Y530-SRC:CSK [cytosol] (Homo sapiens)
Integrin alphaIIb beta3 activation (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Homo sapiens)
p-Y530-SRC:CSK [cytosol] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Homo sapiens)
p-Y530-SRC:CSK [cytosol] (Homo sapiens)
Interaction of integrin alphaIIb beta3 with Fibrinogen (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Homo sapiens)
p-Y530-SRC:CSK [cytosol] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Homo sapiens)
p-Y530-SRC:CSK [cytosol] (Homo sapiens)
Release of CSK from SRC (Homo sapiens)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Homo sapiens)
p-Y530-SRC:CSK [cytosol] (Homo sapiens)
SHC1 bound to integrin alphaIIb beta3 is phosphorylated somehow (Homo sapiens)
Integrin alpha IIb beta 3:p-Y530-SRC:CSK:Talin:RIAM complex:p-Y427-SHC [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Homo sapiens)
p-Y530-SRC:CSK [cytosol] (Homo sapiens)
Integrin alphaIIb beta 3:p(Y530)-SRC:CSK:Talin:RIAM complex:SHC [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Homo sapiens)
p-Y530-SRC:CSK [cytosol] (Homo sapiens)
SHC1 dissociates from integrin alphaIIb beta3 (Homo sapiens)
Integrin alpha IIb beta 3:p-Y530-SRC:CSK:Talin:RIAM complex:p-Y427-SHC [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Homo sapiens)
p-Y530-SRC:CSK [cytosol] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Homo sapiens)
p-Y530-SRC:CSK [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Integrin signaling (Homo sapiens)
Activated integrin alphaIIb beta3 binds SHC1 (Homo sapiens)
Integrin alphaIIb beta 3:p(Y530)-SRC:CSK:Talin:RIAM complex:SHC [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Homo sapiens)
p-Y530-SRC:CSK [cytosol] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Homo sapiens)
p-Y530-SRC:CSK [cytosol] (Homo sapiens)
Clustering of Integrin alphaIIb beta3 complexes (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Homo sapiens)
p-Y530-SRC:CSK [cytosol] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Homo sapiens)
p-Y530-SRC:CSK [cytosol] (Homo sapiens)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Homo sapiens)
p-Y530-SRC:CSK [cytosol] (Homo sapiens)
Integrin alphaIIb beta3 activation (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Homo sapiens)
p-Y530-SRC:CSK [cytosol] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Homo sapiens)
p-Y530-SRC:CSK [cytosol] (Homo sapiens)
Interaction of integrin alphaIIb beta3 with Fibrinogen (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Homo sapiens)
p-Y530-SRC:CSK [cytosol] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Homo sapiens)
p-Y530-SRC:CSK [cytosol] (Homo sapiens)
Release of CSK from SRC (Homo sapiens)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Homo sapiens)
p-Y530-SRC:CSK [cytosol] (Homo sapiens)
SHC1 bound to integrin alphaIIb beta3 is phosphorylated somehow (Homo sapiens)
Integrin alpha IIb beta 3:p-Y530-SRC:CSK:Talin:RIAM complex:p-Y427-SHC [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Homo sapiens)
p-Y530-SRC:CSK [cytosol] (Homo sapiens)
Integrin alphaIIb beta 3:p(Y530)-SRC:CSK:Talin:RIAM complex:SHC [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Homo sapiens)
p-Y530-SRC:CSK [cytosol] (Homo sapiens)
SHC1 dissociates from integrin alphaIIb beta3 (Homo sapiens)
Integrin alpha IIb beta 3:p-Y530-SRC:CSK:Talin:RIAM complex:p-Y427-SHC [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Homo sapiens)
p-Y530-SRC:CSK [cytosol] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Homo sapiens)
p-Y530-SRC:CSK [cytosol] (Homo sapiens)
MAPK family signaling cascades (Homo sapiens)
MAPK1/MAPK3 signaling (Homo sapiens)
RAF/MAP kinase cascade (Homo sapiens)
MAP2K and MAPK activation (Homo sapiens)
Dissociation of RAS:RAF complex (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Homo sapiens)
p-Y530-SRC:CSK [cytosol] (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Homo sapiens)
p-Y530-SRC:CSK [cytosol] (Homo sapiens)
Dual mechanism MAP2K inhibitors bind MAP2Ks (Homo sapiens)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Homo sapiens)
p-Y530-SRC:CSK [cytosol] (Homo sapiens)
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Homo sapiens)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Homo sapiens)
p-Y530-SRC:CSK [cytosol] (Homo sapiens)
Dual mechanism MAPK inhibitors bind MAPKs (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Homo sapiens)
p-Y530-SRC:CSK [cytosol] (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Homo sapiens)
p-Y530-SRC:CSK [cytosol] (Homo sapiens)
MAP2Ks and MAPKs bind to the activated RAF complex (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Homo sapiens)
p-Y530-SRC:CSK [cytosol] (Homo sapiens)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Homo sapiens)
p-Y530-SRC:CSK [cytosol] (Homo sapiens)
MAP2Ks phosphorylate MAPKs (Homo sapiens)
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Homo sapiens)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Homo sapiens)
p-Y530-SRC:CSK [cytosol] (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Homo sapiens)
p-Y530-SRC:CSK [cytosol] (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Homo sapiens)
p-Y530-SRC:CSK [cytosol] (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Homo sapiens)
p-Y530-SRC:CSK [cytosol] (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Homo sapiens)
p-Y530-SRC:CSK [cytosol] (Homo sapiens)
RAF phosphorylates MAP2K dimer (Homo sapiens)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Homo sapiens)
p-Y530-SRC:CSK [cytosol] (Homo sapiens)
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Homo sapiens)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Homo sapiens)
p-Y530-SRC:CSK [cytosol] (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Homo sapiens)
p-Y530-SRC:CSK [cytosol] (Homo sapiens)
Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Homo sapiens)
p-Y530-SRC:CSK [cytosol] (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Homo sapiens)
p-Y530-SRC:CSK [cytosol] (Homo sapiens)
Single mechanism MAPK inhibitors bind phosphorylated MAPK (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Homo sapiens)
p-Y530-SRC:CSK [cytosol] (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK:single mechanism MAPK inhibitors [plasma membrane] (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Homo sapiens)
p-Y530-SRC:CSK [cytosol] (Homo sapiens)
Participants
components
CSK [cytosol]
(Homo sapiens)
MyrG,p-Y530-SRC [plasma membrane]
(Homo sapiens)
Participates
as a component of
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Homo sapiens)
Inferred To
p-Y530-SRC:CSK [cytosol]
(Bos taurus)
p-Y530-SRC:CSK [cytosol]
(Caenorhabditis elegans)
p-Y530-SRC:CSK [cytosol]
(Canis familiaris)
p-Y530-SRC:CSK [cytosol]
(Danio rerio)
p-Y530-SRC:CSK [cytosol]
(Drosophila melanogaster)
p-Y530-SRC:CSK [cytosol]
(Gallus gallus)
p-Y530-SRC:CSK [cytosol]
(Mus musculus)
p-Y530-SRC:CSK [cytosol]
(Rattus norvegicus)
p-Y530-SRC:CSK [cytosol]
(Sus scrofa)
p-Y530-SRC:CSK [cytosol]
(Xenopus tropicalis)
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