Activated Akt1 phosphorylates AKT1S1 (PRAS40)

Stable Identifier
Reaction [transition]
Homo sapiens
Locations in the PathwayBrowser
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

AKT1 phosphorylates AKT1S1 (PRAS40, Proline Rich Akt Substrate 40 kDa) at Thr-246. AKT1S1 is an inhibitory accessory protein of mTORC1. Phosphorylation of AKT1S1 by AKT releases the inhibition of mTORC1.

Literature References
PubMed ID Title Journal Year
17517883 The proline-rich Akt substrate of 40 kDa (PRAS40) is a physiological substrate of mammalian target of rapamycin complex 1

Takehana, K, Yonezawa, K, Tanimura, K, Oshiro, N, Miyamoto, T, Takahashi, R, Avruch, J, Nakashima, A, Hara, K, Yoshino, K, Kikkawa, U, Eguchi, S

J Biol Chem 2007
18372248 Regulation of proline-rich Akt substrate of 40 kDa (PRAS40) function by mammalian target of rapamycin complex 1 (mTORC1)-mediated phosphorylation

Harris, TE, Lawrence JC, Jr, Wang, L

J Biol Chem 2008
12524439 Identification of a proline-rich Akt substrate as a 14-3-3 binding partner

Kovacina, KS, Roth, RA, Schaefer, E, Birnbaum, MJ, Bae, SS, Park, GY, Guzzetta, AW

J Biol Chem 2003
17277771 Insulin signalling to mTOR mediated by the Akt/PKB substrate PRAS40

Kim, DH, Bandhakavi, S, Griffin, TJ, Lee, SI, Vander Haar, E

Nat Cell Biol 2007
17386266 PRAS40 is an insulin-regulated inhibitor of the mTORC1 protein kinase

Kang, SA, Sancak, Y, Thoreen, CC, Spooner, E, Lindquist, RA, Peterson, TR, Sabatini, DM, Carr, SA

Mol Cell 2007
Catalyst Activity

protein serine/threonine kinase activity of p-T308,S473-AKT1 [plasma membrane]

Orthologous Events
Cite Us!