Reactome | NMBR [plasma membrane]

NMBR [plasma membrane]

Stable Identifier

R-HSA-375357

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Neuromedin-B receptor, NMBR_HUMAN

Locations in the PathwayBrowser

Expand all

Signal Transduction (Homo sapiens)

- Signaling by GPCR (Homo sapiens)
  - GPCR downstream signalling (Homo sapiens)
    - G alpha (q) signalling events (Homo sapiens)
      - Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
        
        Bombesin-like receptor:bombesin-like peptide [plasma membrane] (Homo sapiens)
        
        Bombesin-like receptor [plasma membrane] (Homo sapiens)
        
        NMBR [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
        
        Bombesin-like receptor:bombesin-like peptide [plasma membrane] (Homo sapiens)
        
        Bombesin-like receptor [plasma membrane] (Homo sapiens)
        
        NMBR [plasma membrane] (Homo sapiens)
      - Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
        
        Bombesin-like receptor:bombesin-like peptide [plasma membrane] (Homo sapiens)
        
        Bombesin-like receptor [plasma membrane] (Homo sapiens)
        
        NMBR [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
        
        Bombesin-like receptor:bombesin-like peptide [plasma membrane] (Homo sapiens)
        
        Bombesin-like receptor [plasma membrane] (Homo sapiens)
        
        NMBR [plasma membrane] (Homo sapiens)
      - The Ligand:GPCR:Gq complex dissociates (Homo sapiens)
        
        GPCRs that activate Gq/11 [plasma membrane] (Homo sapiens)
        
        Bombesin-like receptor [plasma membrane] (Homo sapiens)
        
        NMBR [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
        
        Bombesin-like receptor:bombesin-like peptide [plasma membrane] (Homo sapiens)
        
        Bombesin-like receptor [plasma membrane] (Homo sapiens)
        
        NMBR [plasma membrane] (Homo sapiens)
  - GPCR ligand binding (Homo sapiens)
    - Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
      - Peptide ligand-binding receptors (Homo sapiens)
        
        Bombesin-like receptors bind bombesin homologues (Homo sapiens)
        
        Bombesin-like receptor [plasma membrane] (Homo sapiens)
        
        NMBR [plasma membrane] (Homo sapiens)
        
        Bombesin-like receptor:bombesin-like peptide [plasma membrane] (Homo sapiens)
        
        Bombesin-like receptor [plasma membrane] (Homo sapiens)
        
        NMBR [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:P28336 NMBR

Gene Names

NMBR

Chain

chain:1-390

Reference Genes

BioGPS Gene:4829 NMBR

COSMIC (genes):NMBR NMBR

CTD Gene:4829 NMBR

dbSNP Gene:4829 NMBR

ENSEMBL:ENSG00000135577 NMBR

HGNC:7843 NMBR

KEGG:hsa:4829 NMBR

Monarch:4829 NMBR

NCBI Gene:4829 NMBR

OMIM:162341 NMBR

UCSC:P28336 NMBR

Reference Transcript

Other Identifiers

11736983_at

17024317

207333_PM_at

207333_at

2977123

2977125

2977126

2977127

2977128

2977129

2977130

2977131

2977132

2977133

2977134

2977140

33996_at

4829

80477_at

8129947

A_23_P70634

GE531954

GO:0002376

GO:0004930

GO:0004946

GO:0005829

GO:0005886

GO:0007186

GO:0007200

GO:0007218

GO:0008188

GO:0008528

GO:0016020

GO:0031989

GO:0032715

GO:0032727

GO:0060089

GO:0090290

GO:0098542

GO:0140374

GO:0160023

GO:1903942

HMNXSV003033744

ILMN_1735704

M73482_at

PH_hs_0025990

TC06002177.hg

TC06002178.hg

g4505406_3p_at

Participates

as a member of

Bombesin-like receptor [plasma membrane] (Homo sapiens)

Inferred To

Homologues of NMBR [plasma membrane] (Drosophila melanogaster)

Homologues of NMBR [plasma membrane] (Sus scrofa)

CCHa1-R [plasma membrane] (Drosophila melanogaster)

Nmbr [plasma membrane] (Mus musculus)

Nmbr [plasma membrane] (Rattus norvegicus)

CCHa2-R [plasma membrane] (Drosophila melanogaster)

NMBR [plasma membrane] (Bos taurus)

NMBR [plasma membrane] (Canis familiaris)

NMBR [plasma membrane] (Gallus gallus)

NMBR [plasma membrane] (Sus scrofa)

Cross References

RefSeq

NP_001311236.1, NP_002502.2, NP_001311237.1

Guide to Pharmacology - Targets

ENSEMBL

ENST00000258042, ENSP00000258042

OpenTargets

ENSG00000135577

ZINC - Substances

NMBR_HUMAN

ZINC - Biogenic

NMBR_HUMAN

ZINC target

P28336

PRO

P28336

GlyGen

P28336

PDB

8H0P

HPA

ENSG00000135577-NMBR

Pharos - Targets

P28336

ZINC - Predictions - Purchasable

NMBR_HUMAN