CDO binds promyogenic cadherins

Stable Identifier
R-HSA-375140
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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In myoblasts, CDO forms cis complexes with the cell–cell adhesion molecule N-cadherin, which is itself involved in regulation of myogenesis. These cadherin complexes contain beta- and alpha-catenins which are important for N-cadherin's effect in myoblast. When CDO binds with ligated cadherins, its intracellular region undergoes a change in conformation and/or posttranslational modi?cation that permits its stable association with Bnip-2 and JLP and, consequently, activation of p38.

Literature References
PubMed ID Title Journal Year
12634428 Promyogenic members of the Ig and cadherin families associate to positively regulate differentiation

Kang, JS, Feinleib, JL, Knox, S, Ketteringham, MA, Krauss, RS

Proc Natl Acad Sci U S A 2003
20160094 N-cadherin ligation, but not Sonic hedgehog binding, initiates Cdo-dependent p38{alpha}/{beta} MAPK signaling in skeletal myoblasts

Lu, M, Krauss, RS

Proc Natl Acad Sci U S A 2010
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