Reactome | CDO binds promyogenic cadherins

CDO binds promyogenic cadherins

Stable Identifier

R-HSA-375140

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

In myoblasts, CDO forms cis complexes with the cell–cell adhesion molecule N-cadherin, which is itself involved in regulation of myogenesis. These cadherin complexes contain beta- and alpha-catenins which are important for N-cadherin's effect in myoblast. When CDO binds with ligated cadherins, its intracellular region undergoes a change in conformation and/or posttranslational modi?cation that permits its stable association with Bnip-2 and JLP and, consequently, activation of p38.

Literature References

PubMed ID	Title	Journal	Year
20160094	N-cadherin ligation, but not Sonic hedgehog binding, initiates Cdo-dependent p38{alpha}/{beta} MAPK signaling in skeletal myoblasts Lu, M, Krauss, RS	Proc Natl Acad Sci U S A	2010
12634428	Promyogenic members of the Ig and cadherin families associate to positively regulate differentiation Kang, JS, Feinleib, JL, Ketteringham, MA, Krauss, RS, Knox, S	Proc Natl Acad Sci U S A	2003