CDO binds promyogenic cadherins

Stable Identifier
R-HSA-375140
Type
Reaction [binding]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
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In myoblasts, CDO forms cis complexes with the cell–cell adhesion molecule N-cadherin, which is itself involved in regulation of myogenesis. These cadherin complexes contain beta- and alpha-catenins which are important for N-cadherin's effect in myoblast. When CDO binds with ligated cadherins, its intracellular region undergoes a change in conformation and/or posttranslational modi?cation that permits its stable association with Bnip-2 and JLP and, consequently, activation of p38.
Literature References
PubMed ID Title Journal Year
20160094 N-cadherin ligation, but not Sonic hedgehog binding, initiates Cdo-dependent p38{alpha}/{beta} MAPK signaling in skeletal myoblasts

Lu, M, Krauss, RS

Proc Natl Acad Sci U S A 2010
12634428 Promyogenic members of the Ig and cadherin families associate to positively regulate differentiation

Kang, JS, Feinleib, JL, Ketteringham, MA, Krauss, RS, Knox, S

Proc Natl Acad Sci U S A 2003
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