Reactome | NPW(33-55) [extracellular region]

NPW(33-55) [extracellular region]

Stable Identifier

R-HSA-374802

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

Neuropeptide W-23, NPW_HUMAN, NPW

Locations in the PathwayBrowser

Expand all

Signal Transduction (Homo sapiens)

- Signaling by GPCR (Homo sapiens)
  - GPCR downstream signalling (Homo sapiens)
    - G alpha (i) signalling events (Homo sapiens)
      - Liganded Gi-activating GPCR acts as a GEF for Gi (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        Neuropeptides B/W receptor:neuropeptides B/W [plasma membrane] (Homo sapiens)
        
        Neuropeptides B/W [extracellular region] (Homo sapiens)
        
        NPW(33-55) [extracellular region] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        Neuropeptides B/W receptor:neuropeptides B/W [plasma membrane] (Homo sapiens)
        
        Neuropeptides B/W [extracellular region] (Homo sapiens)
        
        NPW(33-55) [extracellular region] (Homo sapiens)
      - Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        Neuropeptides B/W receptor:neuropeptides B/W [plasma membrane] (Homo sapiens)
        
        Neuropeptides B/W [extracellular region] (Homo sapiens)
        
        NPW(33-55) [extracellular region] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        Neuropeptides B/W receptor:neuropeptides B/W [plasma membrane] (Homo sapiens)
        
        Neuropeptides B/W [extracellular region] (Homo sapiens)
        
        NPW(33-55) [extracellular region] (Homo sapiens)
      - The Ligand:GPCR:Gi complex dissociates (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        Neuropeptides B/W receptor:neuropeptides B/W [plasma membrane] (Homo sapiens)
        
        Neuropeptides B/W [extracellular region] (Homo sapiens)
        
        NPW(33-55) [extracellular region] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        Neuropeptides B/W receptor:neuropeptides B/W [plasma membrane] (Homo sapiens)
        
        Neuropeptides B/W [extracellular region] (Homo sapiens)
        
        NPW(33-55) [extracellular region] (Homo sapiens)
  - GPCR ligand binding (Homo sapiens)
    - Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
      - Peptide ligand-binding receptors (Homo sapiens)
        
        GPCR neuropeptide receptor binds neuropeptides B and W (Homo sapiens)
        
        Neuropeptides B/W [extracellular region] (Homo sapiens)
        
        NPW(33-55) [extracellular region] (Homo sapiens)
        
        Neuropeptides B/W receptor:neuropeptides B/W [plasma membrane] (Homo sapiens)
        
        Neuropeptides B/W [extracellular region] (Homo sapiens)
        
        NPW(33-55) [extracellular region] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q8N729 NPW

Gene Names

NPW, PPL8, PPNPW

Chain

signal peptide:1-32, peptide:33-62, peptide:33-55, propeptide:65-165

Reference Genes

BioGPS Gene:283869 NPW

COSMIC (genes):NPW NPW

CTD Gene:283869 NPW

dbSNP Gene:283869 NPW

ENSEMBL:ENSG00000183971 NPW

HGNC:30509 NPW

KEGG Gene (Homo sapiens):283869 NPW

Monarch:283869 NPW

NCBI Gene:283869 NPW

OMIM:607997 NPW

UCSC:Q8N729 NPW

Reference Transcript

RefSeq:NM_001099456.2 NPW

Other Identifiers

0103440301

11735531_x_at

16814910

243110_3p_x_at

243110_x_at

283869

3644330

3644331

3644332

3644333

72948_r_at

7992460

A_23_P352799

GO:0001664

GO:0003674

GO:0005515

GO:0005575

GO:0005576

GO:0007165

GO:0007186

GO:0007218

GO:0007631

GO:0008150

Hs.233533.0.A1_3p_at

Hs.233533.0.A1_3p_x_at

TC16000057.hg

TC16001383.hg

Participates

as a member of

Neuropeptides B/W [extracellular region] (Homo sapiens)

Other forms of this molecule

NPW(33-62) [extracellular region]

Inferred To

NPW(33-55) [extracellular region] (Bos taurus)

NPW(33-55) [extracellular region] (Canis familiaris)

NPW(33-55) [extracellular region] (Xenopus tropicalis)

Npw [extracellular region] (Mus musculus)

Npw [extracellular region] (Rattus norvegicus)

npb [extracellular region] (Danio rerio)

NPW [extracellular region] (Gallus gallus)

Cross References

RefSeq

NP_001092926.2

OpenTargets

ENSG00000183971

HPA

ENSG00000183971-NPW

GeneCards

Q8N729

Ensembl

ENST00000566435, ENSG00000183971, ENSP00000456974

PRO

Q8N729

Pharos - Targets

Q8N729