GPCR neuropeptide receptor binds neuropeptides B and W

Stable Identifier
Reaction [binding]
Homo sapiens
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The structurally related (70% identity) orphan G-protein-coupled receptors, neuropeptides B/W receptor 1 and 2 (GPR7 and GPR8 respectively) (O'Dowd BF et al, 1995), are wideley expressed in the central nervous system of humans. Natural ligands identified for these receptors are involved in the regulation of feeding. Neuropeptide B is cleaved into two chains; NPB23 (L7) and NPB29 (L7C). Neuropeptide W is also cleaved into two chains; NPW23 (L8) and NPW30 (L8C) (Tanaka H et al, 2003). Both these peptides can bind to either GPR7 or 8 to elicit their effects downstream.
Literature References
PubMed ID Title Journal Year
12719537 Characterization of a family of endogenous neuropeptide ligands for the G protein-coupled receptors GPR7 and GPR8

Shibata, K, Sakurai, T, King, DS, O'Dowd, BF, Yanagisawa, M, Kurosu, H, Lerner, MR, Richardson, JA, Miyamoto, N, Garry, MG, Williams, SC, Yoshida, T, Yamanaka, A, Tsujino, N, Tanaka, H, Motoike, T

Proc Natl Acad Sci U S A 2003
7590751 The cloning and chromosomal mapping of two novel human opioid-somatostatin-like receptor genes, GPR7 and GPR8, expressed in discrete areas of the brain

Nguyen, T, Rasmussen, JS, Shi, X, O'Dowd, BF, Marchese, A, Heng, HH, Zastawny, R, Cheng, R, Tsui, LC, Scheideler, MA

Genomics 1995
Orthologous Events
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