Somatostatin (growth hormone inhibiting hormone, GHIH; somatotropin release-inhibiting factor, SRIF) (Shen LP et al, 1992) is a peptide hormone that regulates the endocrine system and affects neurotransmission and cell proliferation via interaction with somatostatin receptors 1-5 (Hoyer D et al, 1995). Somatostatin has two active forms produced by alternative cleavage of the single preproprotein and named according to the number of amino acids in the chain; Somatostatin-28 and somatostatin-14. The 5 receptors known to date all couple with pertussis toxin-sensitive G proteins to inhibit adenylate cyclase after ligand binding. They were classified according to the dates they were discovered; SSTR1 and 2 (Yamada Y et al, Jan. 1992), SSTR3 (Yamada Y et al, Dec. 1992) and SSTR4 and SSTR5 (Yamada Y et al, Sep. 1993).
Li, Q, Ihara, Y, Yamada, Y, Kagimoto, S, Masuda, K, Yasuda, K, Seino, S, Someya, Y, Kubota, A, Imura, H
Ihara, Y, Seino, M, Yamada, Y, Kagimoto, S, Reisine, T, Bell, GI, Seino, S, Law, SF, Seino, Y, Kubota, A
Yamada, Y, Post, SR, Bell, GI, Wang, K, Seino, S, Tager, HS
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