Somatostatin receptors bind somatostatin and cortistatin

Stable Identifier
Reaction [binding]
Homo sapiens
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Somatostatin (growth hormone inhibiting hormone, GHIH; somatotropin release-inhibiting factor, SRIF) (Shen LP et al, 1992) is a peptide hormone that regulates the endocrine system and affects neurotransmission and cell proliferation via interaction with somatostatin receptors 1-5 (Hoyer D et al, 1995). Somatostatin has two active forms produced by alternative cleavage of the single preproprotein and named according to the number of amino acids in the chain; Somatostatin-28 and somatostatin-14. The 5 receptors known to date all couple with pertussis toxin-sensitive G proteins to inhibit adenylate cyclase after ligand binding. They were classified according to the dates they were discovered; SSTR1 and 2 (Yamada Y et al, Jan. 1992), SSTR3 (Yamada Y et al, Dec. 1992) and SSTR4 and SSTR5 (Yamada Y et al, Sep. 1993).

Literature References
PubMed ID Title Journal Year
8373420 Cloning, functional expression and pharmacological characterization of a fourth (hSSTR4) and a fifth (hSSTR5) human somatostatin receptor subtype

Li, Q, Ihara, Y, Yamada, Y, Kagimoto, S, Masuda, K, Yasuda, K, Seino, S, Someya, Y, Kubota, A, Imura, H

Biochem Biophys Res Commun 1993
1337145 Somatostatin receptors, an expanding gene family: cloning and functional characterization of human SSTR3, a protein coupled to adenylyl cyclase

Ihara, Y, Seino, M, Yamada, Y, Kagimoto, S, Reisine, T, Bell, GI, Seino, S, Law, SF, Seino, Y, Kubota, A

Mol Endocrinol 1992
1346068 Cloning and functional characterization of a family of human and mouse somatostatin receptors expressed in brain, gastrointestinal tract, and kidney

Yamada, Y, Post, SR, Bell, GI, Wang, K, Seino, S, Tager, HS

Proc Natl Acad Sci U S A 1992
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