Somatostatin receptors bind somatostatin and cortistatin

Stable Identifier
R-HSA-374758
Type
Reaction [binding]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Somatostatin (growth hormone inhibiting hormone, GHIH; somatotropin release-inhibiting factor, SRIF) (Shen LP et al, 1992) is a peptide hormone that regulates the endocrine system and affects neurotransmission and cell proliferation via interaction with somatostatin receptors 1-5 (Hoyer D et al, 1995). Somatostatin has two active forms produced by alternative cleavage of the single preproprotein and named according to the number of amino acids in the chain; Somatostatin-28 and somatostatin-14. The 5 receptors known to date all couple with pertussis toxin-sensitive G proteins to inhibit adenylate cyclase after ligand binding. They were classified according to the dates they were discovered; SSTR1 and 2 (Yamada Y et al, Jan. 1992), SSTR3 (Yamada Y et al, Dec. 1992) and SSTR4 and SSTR5 (Yamada Y et al, Sep. 1993).
Literature References
PubMed ID Title Journal Year
8373420 Cloning, functional expression and pharmacological characterization of a fourth (hSSTR4) and a fifth (hSSTR5) human somatostatin receptor subtype

Li, Q, Ihara, Y, Yamada, Y, Kagimoto, S, Masuda, K, Yasuda, K, Seino, S, Someya, Y, Kubota, A, Imura, H

Biochem Biophys Res Commun 1993
1337145 Somatostatin receptors, an expanding gene family: cloning and functional characterization of human SSTR3, a protein coupled to adenylyl cyclase

Ihara, Y, Seino, M, Yamada, Y, Kagimoto, S, Reisine, T, Bell, GI, Seino, S, Law, SF, Seino, Y, Kubota, A

Mol Endocrinol 1992
1346068 Cloning and functional characterization of a family of human and mouse somatostatin receptors expressed in brain, gastrointestinal tract, and kidney

Yamada, Y, Post, SR, Bell, GI, Wang, K, Seino, S, Tager, HS

Proc Natl Acad Sci U S A 1992
Participants
Participates
Orthologous Events
Authored
Reviewed
Created
Cite Us!