Reactome | Somatostatin receptors bind somatostatin and cortistatin

Somatostatin receptors bind somatostatin and cortistatin

Stable Identifier

R-HSA-374758

Type

Reaction [binding]

Species

Homo sapiens

Compartment

extracellular region, plasma membrane

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Somatostatin receptors bind somatostatin and cortistatin

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Somatostatin (growth hormone inhibiting hormone, GHIH; somatotropin release-inhibiting factor, SRIF) (Shen LP et al, 1992) is a peptide hormone that regulates the endocrine system and affects neurotransmission and cell proliferation via interaction with somatostatin receptors 1-5 (Hoyer D et al, 1995). Somatostatin has two active forms produced by alternative cleavage of the single preproprotein and named according to the number of amino acids in the chain; Somatostatin-28 and somatostatin-14. The 5 receptors known to date all couple with pertussis toxin-sensitive G proteins to inhibit adenylate cyclase after ligand binding. They were classified according to the dates they were discovered; SSTR1 and 2 (Yamada Y et al, Jan. 1992), SSTR3 (Yamada Y et al, Dec. 1992) and SSTR4 and SSTR5 (Yamada Y et al, Sep. 1993).

Literature References

PubMed ID	Title	Journal	Year
1337145	Somatostatin receptors, an expanding gene family: cloning and functional characterization of human SSTR3, a protein coupled to adenylyl cyclase Yamada, Y, Reisine, T, Law, SF, Ihara, Y, Kubota, A, Kagimoto, S, Seino, M, Seino, Y, Bell, GI, Seino, S	Mol Endocrinol	1992
8373420	Cloning, functional expression and pharmacological characterization of a fourth (hSSTR4) and a fifth (hSSTR5) human somatostatin receptor subtype Yamada, Y, Kagimoto, S, Kubota, A, Yasuda, K, Masuda, K, Someya, Y, Ihara, Y, Li, Q, Imura, H, Seino, S	Biochem Biophys Res Commun	1993
1346068	Cloning and functional characterization of a family of human and mouse somatostatin receptors expressed in brain, gastrointestinal tract, and kidney Yamada, Y, Post, SR, Wang, K, Tager, HS, Bell, GI, Seino, S	Proc Natl Acad Sci U S A	1992