L1 binds RanBPM

Stable Identifier
R-HSA-374673
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
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L1 binds RanBPM
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L1 and RanBPM interact with one another and the N-terminus of RanBPM was sufficient for the interaction with L1. RanBPM interacts with RAN, a Ras-like small GTPase that functions as a carrier in nuclear-cytoplasmic exchange. It directly interacts with Sos to activate Ras and induce ERK phosphorylation. RanBPM might function as an adaptor to mediate L1-induced ERK activation.

Literature References
PubMed ID Title Journal Year
16000162 RanBPM is an L1-interacting protein that regulates L1-mediated mitogen-activated protein kinase activation

Lemmon, S, Lemmon, V, Cheng, L

J Neurochem 2005
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Orthologous Events
L1 binds RanBPM (Drosophila melanogaster)
L1 binds RanBPM (Mus musculus)
L1 binds RanBPM (Rattus norvegicus)
Authored
Garapati, P V  (2008-07-30)
Reviewed
Maness, PF  (2010-02-16)
Created
Garapati, P V  (2008-07-30)
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