Phosphorylation and activation of Ezrin

Stable Identifier
R-HSA-374664
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Phosphorylation and activation of Ezrin
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

PIP2 places Ezrin at the membrane in a location to be phosphorylated, and thereby activated, by protein kinase-C theta.

Literature References
PubMed ID Title Journal Year
12154370 ERM proteins and merlin: integrators at the cell cortex

Bretscher, A, Edwards, K, Fehon, RG

Nat Rev Mol Cell Biol 2002
Participants
Input
Output
Participates
as an event of
Catalyst Activity

protein kinase C activity of p-Y90,T538,S676,S695-PRKCQ [plasma membrane]

Physical Entity
p-Y90,T538,S676,S695-PRKCQ [plasma membrane] (Homo sapiens)
Activity
protein kinase C activity (GO:0004697)
Orthologous Events
Phosphorylation and activation of Ezrin (Bos taurus)
Phosphorylation and activation of Ezrin (Caenorhabditis elegans)
Phosphorylation and activation of Ezrin (Canis familiaris)
Phosphorylation and activation of Ezrin (Danio rerio)
Phosphorylation and activation of Ezrin (Drosophila melanogaster)
Phosphorylation and activation of Ezrin (Mus musculus)
Phosphorylation and activation of Ezrin (Rattus norvegicus)
Phosphorylation and activation of Ezrin (Sus scrofa)
Authored
Garapati, P V  (2008-07-16)
Reviewed
Cooper, HM  (2010-02-16)
Created
Garapati, P V  (2008-07-30)
Cite Us!