Reactome | CXCL5(37-114) [extracellular region]

CXCL5(37-114) [extracellular region]

Stable Identifier

R-HSA-373815

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

CXCL5, C-X-C motif chemokine 5, CXCL5_HUMAN

Locations in the PathwayBrowser

Expand all

Signal Transduction (Homo sapiens)

- Signaling by GPCR (Homo sapiens)
  - GPCR downstream signalling (Homo sapiens)
    - G alpha (i) signalling events (Homo sapiens)
      - Liganded Gi-activating GPCR acts as a GEF for Gi (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        CXCR2:CXCR2 ligands [plasma membrane] (Homo sapiens)
        
        CXCR2 ligands [extracellular region] (Homo sapiens)
        
        CXCL5(37-114) [extracellular region] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        CXCR2:CXCR2 ligands [plasma membrane] (Homo sapiens)
        
        CXCR2 ligands [extracellular region] (Homo sapiens)
        
        CXCL5(37-114) [extracellular region] (Homo sapiens)
      - Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        CXCR2:CXCR2 ligands [plasma membrane] (Homo sapiens)
        
        CXCR2 ligands [extracellular region] (Homo sapiens)
        
        CXCL5(37-114) [extracellular region] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        CXCR2:CXCR2 ligands [plasma membrane] (Homo sapiens)
        
        CXCR2 ligands [extracellular region] (Homo sapiens)
        
        CXCL5(37-114) [extracellular region] (Homo sapiens)
      - The Ligand:GPCR:Gi complex dissociates (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        CXCR2:CXCR2 ligands [plasma membrane] (Homo sapiens)
        
        CXCR2 ligands [extracellular region] (Homo sapiens)
        
        CXCL5(37-114) [extracellular region] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        CXCR2:CXCR2 ligands [plasma membrane] (Homo sapiens)
        
        CXCR2 ligands [extracellular region] (Homo sapiens)
        
        CXCL5(37-114) [extracellular region] (Homo sapiens)
  - GPCR ligand binding (Homo sapiens)
    - Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
      - Peptide ligand-binding receptors (Homo sapiens)
        
        Chemokine receptors bind chemokines (Homo sapiens)
        
        Receptor CXCR2 binds ligands CXCL1 to 7 (Homo sapiens)
        
        CXCR2 ligands [extracellular region] (Homo sapiens)
        
        CXCL5(37-114) [extracellular region] (Homo sapiens)
        
        CXCR2:CXCR2 ligands [plasma membrane] (Homo sapiens)
        
        CXCR2 ligands [extracellular region] (Homo sapiens)
        
        CXCL5(37-114) [extracellular region] (Homo sapiens)

External Reference Information

External Reference

UniProt:P42830 CXCL5

Gene Names

CXCL5, ENA78, SCYB5

Chain

signal peptide:1-36, chain:37-114, chain:44-114, chain:45-114

Reference Genes

BioGPS Gene:6374 CXCL5

COSMIC (genes):CXCL5 CXCL5

CTD Gene:6374 CXCL5

dbSNP Gene:6374 CXCL5

ENSEMBL:ENSG00000163735 CXCL5

ENSEMBL:ENSG00000163735.7 CXCL5

HGNC:10642 CXCL5

KEGG Gene (Homo sapiens):6374 CXCL5

Monarch:6374 CXCL5

NCBI Gene:6374 CXCL5

OMIM:600324 CXCL5

Reference Transcript

RefSeq:NM_002994.4 CXCL5

Other Identifiers

11717025_s_at

11728715_at

11728716_x_at

11728717_at

16976827

214974_PM_x_at

214974_x_at

215101_3p_s_at

215101_PM_s_at

215101_s_at

2773368

2773370

2773371

2773372

2773373

2773374

2773375

2773376

35025_at

6374

65970_at

8100977

A_23_P110204

A_24_P277367

GE79799

GO:0002376

GO:0005125

GO:0005515

GO:0005576

GO:0005615

GO:0006935

GO:0006952

GO:0006954

GO:0006955

GO:0007165

GO:0007267

GO:0008009

GO:0008284

GO:0009605

GO:0023052

GO:0030593

GO:0042802

GO:0045236

GO:0048018

GO:0048870

GO:0060326

GO:0061844

GO:0070098

GO:0071222

GO:0098542

GO:0098772

HMNXSV003004980

Hs.287716.0.S1_3p_at

Hs.89714.1.S1_3p_a_at

Hs.89714.1.S1_3p_s_at

Hs.89714.1.S1_3p_x_at

ILMN_1752562

ILMN_2171384

L37036_s_at

PH_hs_0005016

PH_hs_0040428

TC04001283.hg

TC04002588.hg

X78686_at

g4506848_3p_s_at

Participates

as a member of

CXCR2 ligands [extracellular region] (Homo sapiens)

Inferred To

cxcl-c5c [extracellular region] (Danio rerio)

cxcl8a.1 [extracellular region] (Xenopus tropicalis)

cxcl2 [extracellular region] (Xenopus tropicalis)

CXCL5(37-114) [extracellular region] (Canis familiaris)

CXCL5(37-114) [extracellular region] (Danio rerio)

CXCL5(37-114) [extracellular region] (Gallus gallus)

CXCL5(37-114) [extracellular region] (Sus scrofa)

il8l1 [extracellular region] (Danio rerio)

CXCL6 [extracellular region] (Bos taurus)

CXCL8 [extracellular region] (Danio rerio)

CXCL8 [extracellular region] (Xenopus tropicalis)

cxcl8b.2 [extracellular region] (Xenopus tropicalis)

Cxcl5 [extracellular region] (Mus musculus)

Cxcl5 [extracellular region] (Rattus norvegicus)

Homologues of CXCL5(37-114) [extracellular region] (Danio rerio)

Homologues of CXCL5(37-114) [extracellular region] (Xenopus tropicalis)

cxcl8a.2 [extracellular region] (Xenopus tropicalis)

Cross References

RefSeq

NP_002985.1

OpenTargets

ENSG00000163735

GeneCards

P42830

HPA

ENSG00000163735-CXCL5

Ensembl

ENST00000296027, ENSP00000296027, ENSG00000163735

PRO

P42830

Pharos - Targets

P42830

PDB

2MGS