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CXCL6(38-114) [extracellular region]
Stable Identifier
R-HSA-373784
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
CXCL6, C-X-C motif chemokine 6, CXCL6_HUMAN
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (i) signalling events (Homo sapiens)
Liganded Gi-activating GPCR acts as a GEF for Gi (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
CXCR1:CXCR1 ligands [plasma membrane] (Homo sapiens)
CXCR1 ligands [extracellular region] (Homo sapiens)
CXCL6(38-114) [extracellular region] (Homo sapiens)
CXCR2:CXCR2 ligands [plasma membrane] (Homo sapiens)
CXCR2 ligands [extracellular region] (Homo sapiens)
CXCL6(38-114) [extracellular region] (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
CXCR1:CXCR1 ligands [plasma membrane] (Homo sapiens)
CXCR1 ligands [extracellular region] (Homo sapiens)
CXCL6(38-114) [extracellular region] (Homo sapiens)
CXCR2:CXCR2 ligands [plasma membrane] (Homo sapiens)
CXCR2 ligands [extracellular region] (Homo sapiens)
CXCL6(38-114) [extracellular region] (Homo sapiens)
Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
CXCR1:CXCR1 ligands [plasma membrane] (Homo sapiens)
CXCR1 ligands [extracellular region] (Homo sapiens)
CXCL6(38-114) [extracellular region] (Homo sapiens)
CXCR2:CXCR2 ligands [plasma membrane] (Homo sapiens)
CXCR2 ligands [extracellular region] (Homo sapiens)
CXCL6(38-114) [extracellular region] (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
CXCR1:CXCR1 ligands [plasma membrane] (Homo sapiens)
CXCR1 ligands [extracellular region] (Homo sapiens)
CXCL6(38-114) [extracellular region] (Homo sapiens)
CXCR2:CXCR2 ligands [plasma membrane] (Homo sapiens)
CXCR2 ligands [extracellular region] (Homo sapiens)
CXCL6(38-114) [extracellular region] (Homo sapiens)
The Ligand:GPCR:Gi complex dissociates (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
CXCR1:CXCR1 ligands [plasma membrane] (Homo sapiens)
CXCR1 ligands [extracellular region] (Homo sapiens)
CXCL6(38-114) [extracellular region] (Homo sapiens)
CXCR2:CXCR2 ligands [plasma membrane] (Homo sapiens)
CXCR2 ligands [extracellular region] (Homo sapiens)
CXCL6(38-114) [extracellular region] (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
CXCR1:CXCR1 ligands [plasma membrane] (Homo sapiens)
CXCR1 ligands [extracellular region] (Homo sapiens)
CXCL6(38-114) [extracellular region] (Homo sapiens)
CXCR2:CXCR2 ligands [plasma membrane] (Homo sapiens)
CXCR2 ligands [extracellular region] (Homo sapiens)
CXCL6(38-114) [extracellular region] (Homo sapiens)
GPCR ligand binding (Homo sapiens)
Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
Peptide ligand-binding receptors (Homo sapiens)
Chemokine receptors bind chemokines (Homo sapiens)
Receptor CXCR1 binds CXCL6 and CXCL8 ligands (Homo sapiens)
CXCR1 ligands [extracellular region] (Homo sapiens)
CXCL6(38-114) [extracellular region] (Homo sapiens)
CXCR1:CXCR1 ligands [plasma membrane] (Homo sapiens)
CXCR1 ligands [extracellular region] (Homo sapiens)
CXCL6(38-114) [extracellular region] (Homo sapiens)
Receptor CXCR2 binds ligands CXCL1 to 7 (Homo sapiens)
CXCR2 ligands [extracellular region] (Homo sapiens)
CXCL6(38-114) [extracellular region] (Homo sapiens)
CXCR2:CXCR2 ligands [plasma membrane] (Homo sapiens)
CXCR2 ligands [extracellular region] (Homo sapiens)
CXCL6(38-114) [extracellular region] (Homo sapiens)
External Reference Information
External Reference
UniProt:P80162 CXCL6
Gene Names
CXCL6, GCP2, SCYB6
Chain
signal peptide:1-37, chain:38-114, chain:40-114, chain:43-114, chain:46-114
Reference Genes
BioGPS Gene:6372 CXCL6
COSMIC (genes):CXCL6 CXCL6
CTD Gene:6372 CXCL6
dbSNP Gene:6372 CXCL6
ENSEMBL:ENSG00000124875 CXCL6
HGNC:10643 CXCL6
KEGG:hsa:6372 CXCL6
Monarch:6372 CXCL6
NCBI Gene:6372 CXCL6
OMIM:138965 CXCL6
UCSC:P80162 CXCL6
Reference Transcript
RefSeq:NM_002993.3 CXCL6
Other Identifiers
11730801_at
16967779
206336_PM_at
206336_at
2731351
2731352
2731353
2731354
2731355
2731356
2731357
2731358
2731364
2731370
35410_at
6372
8095688
A_14_P129158
A_23_P155755
A_33_P3284266
GE59471
GO:0001776
GO:0002376
GO:0005125
GO:0005515
GO:0005576
GO:0005615
GO:0006935
GO:0006952
GO:0006954
GO:0006955
GO:0007165
GO:0007267
GO:0008009
GO:0008201
GO:0023052
GO:0030593
GO:0032496
GO:0032642
GO:0042119
GO:0042742
GO:0045236
GO:0048018
GO:0048870
GO:0060326
GO:0061844
GO:0070098
GO:0070951
GO:0071222
GO:0098542
GO:0098772
HMNXSV003011397
HMNXSV003040268
ILMN_1779234
ILMN_2161577
TC04000409.hg
TC04002068.hg
U83303_cds2_at
g4506850_3p_at
Participates
as a member of
CXCR1 ligands [extracellular region] (Homo sapiens)
CXCR2 ligands [extracellular region] (Homo sapiens)
Inferred To
CXCL6(38-114) [extracellular region]
(Sus scrofa)
CXCL6 [extracellular region]
(Bos taurus)
CXCL6 [extracellular region]
(Canis familiaris)
Cxcl5 [extracellular region]
(Mus musculus)
Cxcl5 [extracellular region]
(Rattus norvegicus)
Cross References
RefSeq
NP_002984.1
ENSEMBL
ENSG00000124875
,
ENST00000226317
,
ENSP00000226317
OpenTargets
ENSG00000124875
GeneCards
CXCL6
HPA
ENSG00000124875-CXCL6
PRO
P80162
Pharos - Targets
P80162
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P48061 CXCL12
1
CXCL12(22-93) [extracellular region]
(R-HSA-2980693)
0.558
2
UniProt:P13501 CCL5
1
CCL5(24-91) [extracellular region]
(R-HSA-373108)
0.558
2
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