Reactome | DCC heterodimerizes with UNC-5:Netrin-1

DCC heterodimerizes with UNC-5:Netrin-1

Stable Identifier

R-HSA-373713

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

5/5

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UNC-5 uses DCC as a co-receptor and binds to the DCC P1 domain with its DB domain to repel axons at low netrin concentration. It is generally thought that UNC5 receptor alone transduces short range signals whereas DCC-Unc5 complex transduces long range signals important for neuron migration, neurite growth and axon repulsion.

Literature References

PubMed ID	Title	Journal	Year
12810718	Netrin binds discrete subdomains of DCC and UNC5 and mediates interactions between DCC and heparin Longo, PA, Dowd, KA, Leahy, DJ, Geisbrecht, BV, Barfield, RW	J Biol Chem	2003
25123307	The crystal structure of netrin-1 in complex with DCC reveals the bifunctionality of netrin-1 as a guidance cue Zhang, J, Svergun, DI, Wang, JH, Mertens, HDT, Meijers, R, Schenk, G, Sun, X, Zhang, Y, Chegkazi, M, Finci, LI, Wu, Y, Krüger, N	Neuron	2014