DCC heterodimerizes with UNC-5:Netrin-1

Stable Identifier
R-HSA-373713
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane
ReviewStatus
5/5
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DCC heterodimerizes with UNC-5:Netrin-1
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UNC-5 uses DCC as a co-receptor and binds to the DCC P1 domain with its DB domain to repel axons at low netrin concentration. It is generally thought that UNC5 receptor alone transduces short range signals whereas DCC-Unc5 complex transduces long range signals important for neuron migration, neurite growth and axon repulsion.
Literature References
PubMed ID Title Journal Year
12810718 Netrin binds discrete subdomains of DCC and UNC5 and mediates interactions between DCC and heparin

Geisbrecht, BV, Dowd, KA, Barfield, RW, Longo, PA, Leahy, DJ

J Biol Chem 2003
25123307 The crystal structure of netrin-1 in complex with DCC reveals the bifunctionality of netrin-1 as a guidance cue

Finci, LI, Krüger, N, Sun, X, Zhang, J, Chegkazi, M, Wu, Y, Schenk, G, Mertens, HDT, Svergun, DI, Zhang, Y, Wang, JH, Meijers, R

Neuron 2014
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Output
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Authored
Garapati, P V  (2008-07-16)
Reviewed
Cooper, HM  (2010-02-16)
Created
Garapati, P V  (2008-07-16)
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