DCC heterodimerizes with UNC-5:Netrin-1

Stable Identifier
R-HSA-373713
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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UNC-5 uses DCC as a co-receptor and binds to the DCC P1 domain with its DB domain to repel axons at low netrin concentration. It is generally thought that UNC5 receptor alone transduces short range signals whereas DCC-Unc5 complex transduces long range signals important for neuron migration, neurite growth and axon repulsion.

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