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XCL2 [extracellular region]
Stable Identifier
R-HSA-373349
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
Cytokine SCM-1 beta, XCL2_HUMAN
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (q) signalling events (Homo sapiens)
Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
XCR1:XCL1,XCL2 [plasma membrane] (Homo sapiens)
XCL1,XCL2 [extracellular region] (Homo sapiens)
XCL2 [extracellular region] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
XCR1:XCL1,XCL2 [plasma membrane] (Homo sapiens)
XCL1,XCL2 [extracellular region] (Homo sapiens)
XCL2 [extracellular region] (Homo sapiens)
Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
XCR1:XCL1,XCL2 [plasma membrane] (Homo sapiens)
XCL1,XCL2 [extracellular region] (Homo sapiens)
XCL2 [extracellular region] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
XCR1:XCL1,XCL2 [plasma membrane] (Homo sapiens)
XCL1,XCL2 [extracellular region] (Homo sapiens)
XCL2 [extracellular region] (Homo sapiens)
The Ligand:GPCR:Gq complex dissociates (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
XCR1:XCL1,XCL2 [plasma membrane] (Homo sapiens)
XCL1,XCL2 [extracellular region] (Homo sapiens)
XCL2 [extracellular region] (Homo sapiens)
Ligands of GPCRs that activate Gq/11 [extracellular region] (Homo sapiens)
XCL1,XCL2 [extracellular region] (Homo sapiens)
XCL2 [extracellular region] (Homo sapiens)
GPCR ligand binding (Homo sapiens)
Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
Peptide ligand-binding receptors (Homo sapiens)
Chemokine receptors bind chemokines (Homo sapiens)
Receptor CXC1 binds to the ligands lymphotactin and cytokine SCM-1 beta (Homo sapiens)
XCL1,XCL2 [extracellular region] (Homo sapiens)
XCL2 [extracellular region] (Homo sapiens)
XCR1:XCL1,XCL2 [plasma membrane] (Homo sapiens)
XCL1,XCL2 [extracellular region] (Homo sapiens)
XCL2 [extracellular region] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9UBD3 XCL2
Gene Names
XCL2, SCYC2
Chain
signal peptide:1-21, chain:22-114
Reference Genes
BioGPS Gene:6846 XCL2
COSMIC (genes):XCL2 XCL2
CTD Gene:6846 XCL2
dbSNP Gene:6846 XCL2
ENSEMBL:ENSG00000143185 XCL2
HGNC:10646 XCL2
KEGG:hsa:6846 XCL2
Monarch:6846 XCL2
NCBI Gene:6846 XCL2
OMIM:604828 XCL2
UCSC:Q9UBD3 XCL2
Reference Transcript
RefSeq:NM_003175.3 XCL2
Other Identifiers
11735394_s_at
16696114
206366_PM_x_at
206366_x_at
214567_PM_s_at
214567_s_at
2366297
2366302
2366304
2366305
2366306
2443024
2443025
2443026
2443027
2443028
2443029
2443033
2443034
31495_at
31496_g_at
6846
7922127
8180348
A_23_P51534
GE56097
GO:0002376
GO:0003013
GO:0005125
GO:0005515
GO:0005576
GO:0005615
GO:0006935
GO:0006954
GO:0006955
GO:0007165
GO:0008009
GO:0008015
GO:0030335
GO:0048018
GO:0048020
GO:0048245
GO:0048870
GO:0061844
GO:0070098
GO:0098542
GO:0098772
HMNXSV003049087
Hs.174228.0.S1_3p_s_at
ILMN_1666257
ILMN_1718792
TC01003490.hg
Participates
as a member of
XCL1,XCL2 [extracellular region] (Homo sapiens)
Inferred To
XCL1 [extracellular region]
(Bos taurus)
XCL1 [extracellular region]
(Sus scrofa)
Homologues of XCL2 [extracellular region]
(Bos taurus)
Homologues of XCL2 [extracellular region]
(Gallus gallus)
CCL26 [extracellular region]
(Gallus gallus)
CCLi7 [extracellular region]
(Gallus gallus)
CCLi8 [extracellular region]
(Gallus gallus)
Xcl1 [extracellular region]
(Mus musculus)
Xcl1 [extracellular region]
(Rattus norvegicus)
CCL4 [extracellular region]
(Gallus gallus)
CX3CL1 [extracellular region]
(Gallus gallus)
CCLi9 [extracellular region]
(Gallus gallus)
XCL2 [extracellular region]
(Bos taurus)
XCL2 [extracellular region]
(Gallus gallus)
Cross References
RefSeq
NP_003166.1
ENSEMBL
ENSP00000356793
,
ENST00000367819
,
ENSG00000143185
OpenTargets
ENSG00000143185
GeneCards
XCL2
HPA
ENSG00000143185-XCL2
PRO
Q9UBD3
Pharos - Targets
Q9UBD3
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P48061 CXCL12
1
CXCL12(22-93) [extracellular region]
(R-HSA-2980693)
0.558
2
UniProt:P13501 CCL5
1
CCL5(24-91) [extracellular region]
(R-HSA-373108)
0.558
2
UniProt:Q7Z3S9 NOTCH2NLA
3
NOTCH2NLA [extracellular region]
(R-HSA-9908935)
NOTCH2NLA(1-?) [extracellular region]
(R-HSA-9911493)
NOTCH2NLA(?-236) [extracellular region]
(R-HSA-9911490)
0.556
3
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