Reactome | XCL2 [extracellular region]

XCL2 [extracellular region]

Stable Identifier

R-HSA-373349

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

Cytokine SCM-1 beta, XCL2_HUMAN

Locations in the PathwayBrowser

Expand all

Signal Transduction (Homo sapiens)

- Signaling by GPCR (Homo sapiens)
  - GPCR downstream signalling (Homo sapiens)
    - G alpha (q) signalling events (Homo sapiens)
      - Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
        
        XCR1:XCL1,XCL2 [plasma membrane] (Homo sapiens)
        
        XCL1,XCL2 [extracellular region] (Homo sapiens)
        
        XCL2 [extracellular region] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
        
        XCR1:XCL1,XCL2 [plasma membrane] (Homo sapiens)
        
        XCL1,XCL2 [extracellular region] (Homo sapiens)
        
        XCL2 [extracellular region] (Homo sapiens)
      - Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
        
        XCR1:XCL1,XCL2 [plasma membrane] (Homo sapiens)
        
        XCL1,XCL2 [extracellular region] (Homo sapiens)
        
        XCL2 [extracellular region] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
        
        XCR1:XCL1,XCL2 [plasma membrane] (Homo sapiens)
        
        XCL1,XCL2 [extracellular region] (Homo sapiens)
        
        XCL2 [extracellular region] (Homo sapiens)
      - The Ligand:GPCR:Gq complex dissociates (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
        
        XCR1:XCL1,XCL2 [plasma membrane] (Homo sapiens)
        
        XCL1,XCL2 [extracellular region] (Homo sapiens)
        
        XCL2 [extracellular region] (Homo sapiens)
        
        Ligands of GPCRs that activate Gq/11 [extracellular region] (Homo sapiens)
        
        XCL1,XCL2 [extracellular region] (Homo sapiens)
        
        XCL2 [extracellular region] (Homo sapiens)
  - GPCR ligand binding (Homo sapiens)
    - Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
      - Peptide ligand-binding receptors (Homo sapiens)
        
        Chemokine receptors bind chemokines (Homo sapiens)
        
        Receptor CXC1 binds to the ligands lymphotactin and cytokine SCM-1 beta (Homo sapiens)
        
        XCL1,XCL2 [extracellular region] (Homo sapiens)
        
        XCL2 [extracellular region] (Homo sapiens)
        
        XCR1:XCL1,XCL2 [plasma membrane] (Homo sapiens)
        
        XCL1,XCL2 [extracellular region] (Homo sapiens)
        
        XCL2 [extracellular region] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9UBD3 XCL2

Gene Names

XCL2, SCYC2

Chain

signal peptide:1-21, chain:22-114

Reference Genes

BioGPS Gene:6846 XCL2

COSMIC (genes):XCL2 XCL2

CTD Gene:6846 XCL2

dbSNP Gene:6846 XCL2

ENSEMBL:ENSG00000143185 XCL2

HGNC:10646 XCL2

KEGG:hsa:6846 XCL2

Monarch:6846 XCL2

NCBI Gene:6846 XCL2

OMIM:604828 XCL2

UCSC:Q9UBD3 XCL2

Reference Transcript

RefSeq:NM_003175.3 XCL2

Other Identifiers

11735394_s_at

16696114

206366_PM_x_at

206366_x_at

214567_PM_s_at

214567_s_at

2366297

2366302

2366304

2366305

2366306

2443024

2443025

2443026

2443027

2443028

2443029

2443033

2443034

31495_at

31496_g_at

6846

7922127

8180348

A_23_P51534

GE56097

GO:0002376

GO:0003013

GO:0005125

GO:0005515

GO:0005576

GO:0005615

GO:0006935

GO:0006954

GO:0006955

GO:0007165

GO:0008009

GO:0008015

GO:0030335

GO:0048018

GO:0048020

GO:0048245

GO:0048870

GO:0061844

GO:0070098

GO:0098542

GO:0098772

HMNXSV003049087

Hs.174228.0.S1_3p_s_at

ILMN_1666257

ILMN_1718792

TC01003490.hg

Participates

as a member of

XCL1,XCL2 [extracellular region] (Homo sapiens)

Inferred To

XCL1 [extracellular region] (Bos taurus)

XCL1 [extracellular region] (Sus scrofa)

Homologues of XCL2 [extracellular region] (Bos taurus)

Homologues of XCL2 [extracellular region] (Gallus gallus)

CCL26 [extracellular region] (Gallus gallus)

CCLi7 [extracellular region] (Gallus gallus)

CCLi8 [extracellular region] (Gallus gallus)

Xcl1 [extracellular region] (Mus musculus)

Xcl1 [extracellular region] (Rattus norvegicus)

CCL4 [extracellular region] (Gallus gallus)

CX3CL1 [extracellular region] (Gallus gallus)

CCLi9 [extracellular region] (Gallus gallus)

XCL2 [extracellular region] (Bos taurus)

XCL2 [extracellular region] (Gallus gallus)

Cross References

RefSeq

NP_003166.1

ENSEMBL

ENSP00000356793, ENST00000367819, ENSG00000143185

OpenTargets

ENSG00000143185

GeneCards

XCL2

HPA

ENSG00000143185-XCL2

PRO

Q9UBD3

Pharos - Targets

Q9UBD3

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P48061 CXCL12	1	CXCL12(22-93) [extracellular region] (R-HSA-2980693)	0.558	2
UniProt:P13501 CCL5	1	CCL5(24-91) [extracellular region] (R-HSA-373108)	0.558	2
UniProt:Q7Z3S9 NOTCH2NLA	3	NOTCH2NLA [extracellular region] (R-HSA-9908935) NOTCH2NLA(1-?) [extracellular region] (R-HSA-9911493) NOTCH2NLA(?-236) [extracellular region] (R-HSA-9911490)	0.556	3