Reactome | CCL27 [extracellular region]

CCL27 [extracellular region]

Stable Identifier

R-HSA-373098

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

C-C motif chemokine 27, CCL27_HUMAN

Locations in the PathwayBrowser

Expand all

Signal Transduction (Homo sapiens)

- Signaling by GPCR (Homo sapiens)
  - GPCR downstream signalling (Homo sapiens)
    - G alpha (i) signalling events (Homo sapiens)
      - Liganded Gi-activating GPCR acts as a GEF for Gi (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        CCR10:CCL27,28 [plasma membrane] (Homo sapiens)
        
        CCL27,28 [extracellular region] (Homo sapiens)
        
        CCL27 [extracellular region] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        CCR10:CCL27,28 [plasma membrane] (Homo sapiens)
        
        CCL27,28 [extracellular region] (Homo sapiens)
        
        CCL27 [extracellular region] (Homo sapiens)
      - Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        CCR10:CCL27,28 [plasma membrane] (Homo sapiens)
        
        CCL27,28 [extracellular region] (Homo sapiens)
        
        CCL27 [extracellular region] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        CCR10:CCL27,28 [plasma membrane] (Homo sapiens)
        
        CCL27,28 [extracellular region] (Homo sapiens)
        
        CCL27 [extracellular region] (Homo sapiens)
      - The Ligand:GPCR:Gi complex dissociates (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        CCR10:CCL27,28 [plasma membrane] (Homo sapiens)
        
        CCL27,28 [extracellular region] (Homo sapiens)
        
        CCL27 [extracellular region] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        CCR10:CCL27,28 [plasma membrane] (Homo sapiens)
        
        CCL27,28 [extracellular region] (Homo sapiens)
        
        CCL27 [extracellular region] (Homo sapiens)
  - GPCR ligand binding (Homo sapiens)
    - Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
      - Peptide ligand-binding receptors (Homo sapiens)
        
        Chemokine receptors bind chemokines (Homo sapiens)
        
        Receptor CCR10 binds CCL27 and 28 ligands (Homo sapiens)
        
        CCL27,28 [extracellular region] (Homo sapiens)
        
        CCL27 [extracellular region] (Homo sapiens)
        
        CCR10:CCL27,28 [plasma membrane] (Homo sapiens)
        
        CCL27,28 [extracellular region] (Homo sapiens)
        
        CCL27 [extracellular region] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9Y4X3 CCL27

Gene Names

CCL27, ILC, SCYA27

Chain

signal peptide:1-24, chain:25-112

Reference Genes

BioGPS Gene:10850 CCL27

COSMIC (genes):CCL27 CCL27

CTD Gene:10850 CCL27

dbSNP Gene:10850 CCL27

ENSEMBL:ENSG00000213927 CCL27

ENSEMBL_homo_sapiens_GENE:ENSG00000213927.4 CCL27

HGNC:10626 CCL27

KEGG Gene (Homo sapiens):10850 CCL27

Monarch:10850 CCL27

NCBI Gene:10850 CCL27

OMIM:604833 CCL27

UCSC:Q9Y4X3 CCL27

Reference Transcript

RefSeq:NM_006664.3 CCL27

Other Identifiers

10850

11715295_s_at

207955_PM_at

207955_at

31644_at

3204262

3204263

3204265

3204267

A_23_P135248

GE81666

GO:0002376

GO:0005125

GO:0005515

GO:0005576

GO:0005615

GO:0006935

GO:0006955

GO:0007165

GO:0007267

GO:0008009

GO:0023052

GO:0031728

GO:0048018

GO:0048870

GO:0060326

GO:0098772

HMNXSV003004475

PH_hs_0012613

TC09002914.hg

g5730034_3p_at

Participates

as a member of

CCL27,28 [extracellular region] (Homo sapiens)

Inferred To

ccl-c11b [extracellular region] (Danio rerio)

CCL27 [extracellular region] (Bos taurus)

CCL27 [extracellular region] (Sus scrofa)

Ccl27 [extracellular region] (Mus musculus)

Ccl27 [extracellular region] (Rattus norvegicus)

Cross References

RefSeq

NP_006655.1

OpenTargets

ENSG00000213927

HPA

ENSG00000213927-CCL27

GeneCards

Q9Y4X3

Ensembl

ENSP00000259631, ENST00000259631, ENSG00000213927

PRO

Q9Y4X3

Pharos - Targets

Q9Y4X3

PDB

2KUM