Crk binding to p130cas

Stable Identifier
R-HSA-372697
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
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Crk binding to p130cas
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Crk is an adaptor protein with one SH2 and two SH3 domains. It is involved in integrin mediated signalling and is recruited to the focal adhesion complexes by interacting with p130Cas or paxillin through its SH2 domain.
Literature References
PubMed ID Title Journal Year
10777559 Crk activation of JNK via C3G and R-Ras

Mochizuki, N, Ohba, Y, Kobayashi, S, Otsuka, N, Graybiel, AM, Tanaka, S, Matsuda, M

J Biol Chem 2000
16581250 p130Cas: a versatile scaffold in signaling networks

Defilippi, P, Di Stefano, P, Cabodi, S

Trends Cell Biol 2006
12640026 Focal adhesion kinase: the first ten years

Parsons, JT

J Cell Sci 2003
Participants
Input
Output
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as an event of
Orthologous Events
Crk binding to p130cas (Bos taurus)
Crk binding to p130cas (Canis familiaris)
Crk binding to p130cas (Gallus gallus)
Crk binding to p130cas (Mus musculus)
Crk binding to p130cas (Rattus norvegicus)
Crk binding to p130cas (Sus scrofa)
Authored
Garapati, P V  (2008-06-16)
Reviewed
Shattil, SJ  (2008-09-16)
Created
Garapati, P V  (2008-06-27)
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