Reactome | SOD1:Zn2+ apoenzyme binds CCS:Zn2+:2xCu1+

SOD1:Zn2+ apoenzyme binds CCS:Zn2+:2xCu1+

Stable Identifier

R-HSA-3697860

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

SOD1:Zn2+ apoenzyme binds CCS:Zn2+:2xCu1+

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Copper chaperone of superoxide dismutase (CCS) transfers a copper(I) atom to a SOD1 monomer that already contains a Zn atom (Culotta et al. 1997, Casareno et al. 1998, Rae et al. 2001, Brown et al. 2004, Banci et al. 2012). The reaction proceeds by a two step mechanism in which SOD1 first forms heterodimers with CCS (Rae et al. 2001, Banci et al. 2012).

Literature References

PubMed ID	Title	Journal	Year
9295278	The copper chaperone for superoxide dismutase Culotta, VC, Klomp, LW, Strain, J, Casareno, RL, Krems, B, Gitlin, JD	J. Biol. Chem.	1997
9726962	The copper chaperone CCS directly interacts with copper/zinc superoxide dismutase Casareno, RL, Waggoner, D, Gitlin, JD	J. Biol. Chem.	1998
15064408	Oxygen and the copper chaperone CCS regulate posttranslational activation of Cu,Zn superoxide dismutase Brown, NM, Torres, AS, Doan, PE, O'Halloran, TV	Proc. Natl. Acad. Sci. U.S.A.	2004
22869735	Human superoxide dismutase 1 (hSOD1) maturation through interaction with human copper chaperone for SOD1 (hCCS) Banci, L, Bertini, I, Cantini, F, Kozyreva, T, Massagni, C, Palumaa, P, Rubino, JT, Zovo, K	Proc. Natl. Acad. Sci. U.S.A.	2012
16880213	The effects of glutaredoxin and copper activation pathways on the disulfide and stability of Cu,Zn superoxide dismutase Carroll, MC, Outten, CE, Proescher, JB, Rosenfeld, L, Watson, WH, Whitson, LJ, Hart, PJ, Jensen, LT, Cizewski Culotta, V	J. Biol. Chem.	2006
18703498	Different regulation of wild-type and mutant Cu,Zn superoxide dismutase localization in mammalian mitochondria Kawamata, H, Manfredi, G	Hum. Mol. Genet.	2008
11018045	Mechanism of Cu,Zn-superoxide dismutase activation by the human metallochaperone hCCS Rae, TD, Torres, AS, Pufahl, RA, O'Halloran, TV	J. Biol. Chem.	2001