Iodide is organified

Stable Identifier
R-HSA-350901
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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The first step in the biogenesis of thyroid hormones is the oxidation of iodide (I-) by H2O2/peroxidase after being taken up by the thyroid gland. This event is known as organification.

Literature References
PubMed ID Title Journal Year
1722671 Formation of molecular iodine during oxidation of iodide by the peroxidase/H2O2 system. Implications for antithyroid therapy

Lagorce, JF, Thomes, JC, Catanzano, G, Buxeraud, J, Raby, M, Raby, C

Biochem Pharmacol 1991
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
peroxidase activity of TPO [plasma membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created
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