CETP + spherical HDL + torcetrapib => CETP:spherical HDL:torcetrapib complex

Stable Identifier
R-HSA-349404
Type
Reaction [binding]
Species
Homo sapiens
Compartment
extracellular region
ReviewStatus
5/5
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CETP + spherical HDL + torcetrapib => CETP:spherical HDL:torcetrapib complex
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Torcetrapib associates with a molecule of CETP and a spherical HDL particle to form a stable complex, thus trapping CETP and inhibiting CETP-mediated lipid transfer between HDL and LDL (Clark et al. 2006). Torcetrapib was a drug developed to treat hypercholesterolemia and prevent cardiovascular disease but its development was stopped when phase III studies showed excessive all-cause mortality in the treatment group (Howes & Kostner 2007).
Literature References
PubMed ID Title Journal Year
16326978 Description of the torcetrapib series of cholesteryl ester transfer protein inhibitors, including mechanism of action

Cunningham, D, Clark, RW, Ruggeri, RB, Bamberger, MJ

J Lipid Res 2006
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Orthologous Events
CETP + spherical HDL + torcetrapib => CETP:spherical HDL:torcetrapib complex (Gallus gallus)
Authored
D'Eustachio, P  (2008-05-12)
Reviewed
Jassal, B  (2008-06-13)
Created
D'Eustachio, P  (2008-05-08)
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