CETP + spherical HDL + torcetrapib => CETP:spherical HDL:torcetrapib complex

Stable Identifier
R-HSA-349404
Type
Reaction
Species
Homo sapiens
Compartment
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Summation

Torcetrapib associates with a molecule of CETP and a spherical HDL particle to form a stable complex, thus trapping CETP and inhibiting CETP-mediated lipid transfer between HDL and LDL (Clark et al. 2006).

Literature References
PubMed ID Title Journal Year
16326978 Description of the torcetrapib series of cholesteryl ester transfer protein inhibitors, including mechanism of action

Clark, RW, Ruggeri, RB, Cunningham, D, Bamberger, MJ

J Lipid Res 2006
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